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Cryoglobulins (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of abnormal proteins called cryoglobulins in your blood. These proteins can clump together when the blood cools, potentially causing blockages or damage to blood vessels.

Quick summary

["Cryoglobulins may indicate conditions like vasculitis or infections that affect your immune system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
33649-5
Short code
Cryoglob IgG Ser-mCnc
Synonyms
Cryoglob IgG Ser-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are abnormal proteins found in the blood that can form clumps when exposed to lower temperatures. These clumps can block small blood vessels, leading to symptoms like fatigue, swelling, or skin changes. They are often linked to immune system disorders or infections.

Why Might You Need This Test?

This test helps diagnose or evaluate conditions where abnormal proteins in your blood may cause health issues, especially in cold environments or when blood vessels are affected.

How Is the Test Performed?

The test involves sending a small amount of your blood to a lab, where it is examined for proteins that can clump when cooled. Results help identify potential immune or infectious conditions.

What Do Results Mean?

Results can indicate whether you have an immune-related disorder or an infection that affects your blood vessels. Your doctor will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Levels

Frequently asked questions

What causes cryoglobulins to appear in the blood?
Cryoglobulins can be caused by underlying conditions such as autoimmune diseases (like rheumatoid arthritis), chronic infections (like hepatitis C), or certain lymphoproliferative disorders. Stress, medications, or other immune system triggers may also play a role.
How long does it take to get results from this test?
Test results are typically available within 1 to 3 business days, depending on lab processing times. Your healthcare provider will contact you once results are ready.
Can lifestyle changes help manage cryoglobulinemia?
While lifestyle changes like managing infections, controlling inflammation (e.g., through medications), or avoiding cold exposure may help symptoms, they do not cure cryoglobulinemia. Always follow your doctor’s recommendations for treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy