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Cryoglobulin Profile (Screening)

Published: August 9, 2026Updated: August 16, 2026

This test measures proteins called cryoglobulins in your blood, which can form clumps when the blood cools. These clumps may cause symptoms like swelling, fatigue, or skin changes.

Quick summary

["Cryoglobulins are abnormal proteins that may indicate conditions like lupus, infections, or certain cancers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55849-4
Short code
Cryoglob IgM moncl Ser Ql
Synonyms
Cryoglob IgM moncl Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is a Cryoglobulin Profile Used For?

Doctors use this test to diagnose or monitor conditions linked to abnormal protein clumping, such as cryoglobulinemia—a rare blood disorder. It may also help assess symptoms like joint pain, skin rashes, or unexplained fatigue that don’t fit other diagnoses.

How Is the Test Done?

A blood sample is drawn from a vein in your arm. The lab tests the blood for cryoglobulins using a method called electrophoresis, which separates proteins based on size and charge. Results are qualitative (positive/negative) rather than a numeric value.

What Are Possible Results?

A positive result means abnormal proteins were found that clump when cooled. This may signal conditions like chronic infections, autoimmune diseases, or certain cancers. A negative result means no abnormal clumping was detected.

What Does a Positive Result Mean?

A positive cryoglobulin screen may raise concerns for conditions like mixed cryoglobulinemia (often linked to hepatitis C), rheumatoid arthritis, or other autoimmune disorders. Follow-up testing may include additional bloodwork or biopsies to explore the cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Screen

Frequently asked questions

Why did my doctor order this test?
Your doctor may recommend it if you have symptoms like unexplained joint pain, skin changes, fatigue, or unexplained swelling—especially if other tests didn’t explain your concerns.
What if my test is positive?
A positive result may mean you have a condition like cryoglobulinemia or an autoimmune/infectious process. Your doctor will likely order more tests (like blood cultures or additional protein studies) to find the cause and guide treatment.
Can I prevent cryoglobulins from forming?
While you can’t prevent cryoglobulin formation, managing conditions like infections, autoimmune diseases, or liver issues (if applicable) may help reduce symptoms. Follow your doctor’s advice for monitoring and treatment.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy