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Cryoglobulin Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence and type of proteins called cryoglobulins in your blood. Cryoglobulins are abnormal proteins that can clump together (precipitate) when the blood cools, potentially causing symptoms or complications.

Quick summary

["Cryoglobulins may indicate underlying conditions like infections, autoimmune diseases, or certain cancers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110836-4
Short code
Cryoglob IgM Msmt Ser
Synonyms
Cryoglob IgM Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are abnormal proteins found in your blood that can form clumps when exposed to lower temperatures. These clumps can block small blood vessels, leading to symptoms like swelling, pain, or skin changes. They may also be linked to immune system dysfunction.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms such as joint pain, rashes, fatigue, or unexplained infections. It’s also used to diagnose or monitor conditions like lupus, hepatitis, or certain types of lymphoma.

Common Conditions Linked to Cryoglobulins

Cryoglobulins are often associated with autoimmune diseases (e.g., mixed cryoglobulinemia), chronic infections (e.g., hepatitis C), or rare blood disorders. They can cause vascular issues or immune system overactivity.

How Is the Test Performed?

A blood sample is drawn from a vein in your arm. The blood is then tested in a lab to detect and analyze cryoglobulins using electrophoresis, a method that separates proteins based on size and charge.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Cryoglobulins play a key role in diagnosing conditions that affect blood vessels and immune function. High levels may signal an active immune response, infection, or a need for further medical evaluation to manage symptoms or underlying causes.

Short name

Cryoglobulins

Frequently asked questions

What Does a Positive Result Mean?
A positive result means cryoglobulins are present in your blood. This doesn’t always mean you have a serious condition, but it may prompt further testing to identify the cause, such as infections or autoimmune diseases.
How Often Should I Get This Test?
Your doctor will determine how often you need this test based on your symptoms, medical history, and treatment plan. Follow-up tests may be scheduled if you have ongoing concerns or if your condition changes.
Can I Take Anything Before the Test?
You can eat and drink normally before the test, but avoid heavy exercise or stress that day. Let your healthcare provider know about any medications or supplements you’re taking, as they may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy