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Cryoglobulin Profile (Cold Agglutinin Test)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence of cryoglobulins, which are abnormal proteins in your blood that form clumps when cooled and may dissolve when warmed. It helps identify conditions linked to cold sensitivity in blood.

Quick summary

["Cryoglobulins can indicate underlying health issues that may require further medical evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
40578-7
Short code
Cryoglob IgM Ser Cold-mCnc
Synonyms
Cryoglob IgM Ser Cold-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cold-incubation
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is a Cryoglobulin Profile Used For?

Cryoglobulins are often checked if you have symptoms like cold sensitivity, unexplained fatigue, joint pain, or signs of circulation problems. They may also be evaluated in people with certain autoimmune diseases or infections, such as hepatitis C.

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The blood is then tested to detect the formation of clumps when cooled and their behavior upon rewarming, often using a specialized centrifuge or visual inspection for agglutination.

What Are Possible Results?

Results may show the presence of cryoglobulins, their type (monomeric, mixed, or monoclonal), and whether they are reactive at specific temperatures. These findings help guide further testing or treatment plans.

Common Conditions Linked to Cryoglobulins

Cryoglobulinemia can be associated with autoimmune disorders, chronic infections (like hepatitis C), or certain cancers. Symptoms may include skin changes, nerve damage, or organ involvement.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Profile

Frequently asked questions

Why might my doctor order this test?
Your doctor may recommend this test if you have symptoms like cold intolerance, unexplained fatigue, or signs of circulation issues, especially if they suspect an underlying autoimmune condition or infection.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Follow-up with your healthcare provider to discuss findings and next steps.
Can lifestyle changes help with cryoglobulins?
While lifestyle changes like managing infections, avoiding extreme cold exposure, or treating underlying autoimmune conditions may help symptoms, cryoglobulins themselves are not typically altered by diet or daily habits without medical intervention.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy