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Cryoglobulin Profile (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the presence and type of proteins called cryoglobulins in your blood, which can form clumps when the blood cools. These proteins may be linked to certain autoimmune conditions or infections.

Quick summary

["Cryoglobulins can cause symptoms like fatigue, joint pain, or skin changes when they form in cold temperatures."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108026-6
Short code
Cryoglob Msmt Ser
Synonyms
Cryoglob Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Are Cryoglobulins?

Cryoglobulins are abnormal proteins found in your blood that can clump together when exposed to cooler temperatures. Normally, these proteins stay dissolved in warm blood. When they form clumps, they can block small blood vessels, leading to symptoms like swelling, pain, or skin rashes.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like unexplained fatigue, joint pain, or skin changes that don’t improve with treatment. It can also be used to monitor conditions like certain autoimmune diseases or infections that affect blood vessels.

What to Expect During the Test

A blood sample will be drawn from a vein in your arm. You may feel a slight pinch, but it usually doesn’t cause significant discomfort. The blood is then sent to a lab for analysis to detect cryoglobulins.

Possible Causes and Conditions

Cryoglobulinemia (the presence of cryoglobulins) can be linked to conditions such as autoimmune diseases (like rheumatoid arthritis), chronic infections (like hepatitis C), or certain cancers. Some people may have cryoglobulins without symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulins

Frequently asked questions

What does a positive result mean?
A positive result means cryoglobulins are present in your blood. This doesn’t always mean you have a serious condition, but it may signal an underlying problem like an infection, autoimmune disease, or another health concern that needs further investigation.
How is this test different from other blood tests?
Unlike standard blood tests that measure specific substances (like glucose or cholesterol), this test checks for abnormal proteins that can clump in cold temperatures. It’s often used alongside other tests to diagnose conditions affecting blood vessels or immune function.
Can lifestyle changes affect cryoglobulin levels?
While lifestyle factors like diet and exercise can support overall health, they may not directly influence cryoglobulin levels. If you have a known condition linked to cryoglobulins, your doctor will focus on treatments tailored to your specific diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy