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: Cryoglobulin, Serum or Plasma, by Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

: This test measures the amount of cryoglobulins—proteins that clump together in cold temperatures—present in a sample of serum or plasma.

Quick summary

[": Cryoglobulin testing helps detect abnormal cold-sensitive proteins that can affect blood vessels and circulation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
2168-3
Short code
Cryoglob SerPl-mCnc
Synonyms
Cryoglob SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What Are Cryoglobulins?

: Cryoglobulins are proteins in the blood that become insoluble and form clumps when the sample is cooled below normal body temperature. When warmed again, they typically dissolve. Their presence can indicate an underlying immune or blood condition.

: How the Test Is Done

: A blood sample is collected and transported to the laboratory, where it is kept warm and then chilled to allow any cryoglobulins to separate out. The amount that precipitates is measured and reported as a mass concentration in the serum or plasma.

: Why Your Doctor Ordered It

: Your doctor may order this test if you have symptoms such as skin rash, joint pain, numbness, or circulation problems in cold temperatures, or if you have a condition that can be associated with cryoglobulins, such as certain infections or autoimmune diseases.

: What the Results Mean

: A detectable or elevated level of cryoglobulins may suggest an underlying condition and is usually interpreted alongside your symptoms and other test results. Results should be discussed with your healthcare provider for proper context.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

: Cryoglobulin testing supports the evaluation of conditions such as cryoglobulinemic vasculitis and certain autoimmune, infectious, or blood disorders. Because results depend on proper sample handling and can vary, they are best interpreted together with clinical findings and additional laboratory tests.

Short name

: Cryoglobulins

Frequently asked questions

: Do I need to fast before this test?
: Fasting is generally not required unless your healthcare provider instructs otherwise. Follow any specific preparation instructions you are given.
: Why is special handling needed for this sample?
: The sample must be kept at body temperature until it reaches the laboratory and then chilled in a controlled way, because cryoglobulins only separate out under specific temperature conditions.
: Can medications affect the result?
: Some medications and underlying conditions may influence results. Tell your provider about all medications and supplements you take before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy