Cryoglobulin Profile (Cold-Sensitive Immunoglobulin Screening)
This test measures proteins in your blood that thicken and form clumps when exposed to cold temperatures. These proteins, called cryoglobulins, may indicate an underlying immune system issue.
["Cold-sensitive proteins in your blood could signal immune disorders or other conditions needing further evaluation."]
Key facts at a glance
- LOINC
- 12201-0
- Short code
- Cryoglob Ser Ql 1D Cold Inc
- Synonyms
- Cryoglob Ser Ql 1D Cold Inc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- d-cold-incubation
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test if you have symptoms like fatigue, joint pain, or swelling, or if they suspect conditions such as cryoglobulinemia, lupus, or other autoimmune diseases. It helps identify whether cold exposure triggers abnormal protein clumping in your bloodstream.
What to Expect Before the Test
No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. If you have a history of blood clots or bleeding issues, let your provider know beforehand.
What Happens During the Test?
Blood is collected in a tube and sent to a lab. The sample is then exposed to cold temperatures to detect any clumping. If clumps form, they indicate the presence of cryoglobulins.
What Are Possible Results?
Results are qualitative (positive or negative) for cryoglobulin presence. A positive result means cold-sensitive proteins were found, which may prompt further testing or evaluation of symptoms.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results suggest cryoglobulins may be linked to conditions like mixed cryoglobulinemia (a combination of immune disorders), infections, or other autoimmune diseases. These proteins can cause symptoms like skin rashes, nerve damage, or organ damage if untreated. Follow-up testing or treatment may be recommended based on your symptoms and provider’s assessment.
Short name
Cryoglobulin Test
Frequently asked questions
What Does a Positive Test Mean?
Will I Need More Testing?
Can I Take Anything Before the Test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy