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Cryoglobulin Profile (Cold-Sensitive Immunoglobulin Detection)

Published: August 9, 2026Updated: August 16, 2026

This test measures proteins in your blood that thicken when exposed to cold, which may indicate an underlying immune system condition.

Quick summary

["Cold-sensitive proteins in your blood may signal immune disorders or other health concerns."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12200-2
Short code
Cryoglob Ser Ql 4h Cold Inc
Synonyms
Cryoglob Ser Ql 4h Cold Inc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
h-cold-incubation
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is a Cryoglobulin?

Cryoglobulins are abnormal proteins in your blood that become solid (gel-like) when the temperature drops. They can form clumps that may block blood flow, causing pain, swelling, or other symptoms. This test helps identify their presence.

Why Is This Test Done?

Doctors may order this test if you have symptoms like joint pain, fatigue, or skin changes that worsen in cold weather. It can also help diagnose conditions such as infections, autoimmune diseases, or certain cancers.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then tested to detect cold-sensitive proteins that may form clumps when cooled.

What Are Possible Results?

Results may show the presence of cryoglobulins, which can vary in type (monoclonal, mixed, or polyclonal). A positive result may require further testing to determine the cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Cryoglobulin Screen

Frequently asked questions

Cryoglobulins are often linked to conditions like cryoglobulinemia (a blood disorder), infections (e.g., hepatitis), or autoimmune diseases. Early detection can guide treatment decisions.
This test alone does not diagnose a specific condition but helps identify potential risks. Follow-up tests may be needed to explore underlying causes.
What does a positive result mean?
A positive result suggests the presence of abnormal proteins that may cause health issues. Your doctor will discuss next steps, such as additional blood tests or further evaluation.
Can lifestyle changes help manage cryoglobulins?
While lifestyle adjustments (like avoiding cold exposure) may help manage symptoms, treatment often requires medical intervention, such as medications to control immune activity.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy