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Cryoglobulin Detection (Cold-Sensitive)

Published: August 9, 2026Updated: August 16, 2026

This test checks for abnormal proteins called cryoglobulins that may appear in your blood and become sticky when cold, potentially causing blockages or inflammation.

Quick summary

["Cryoglobulins can signal underlying conditions like infections, autoimmune diseases, or certain cancers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12206-9
Short code
Cryoglob Ser Ql 6D Cold Inc
Synonyms
Cryoglob Ser Ql 6D Cold Inc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
d-cold-incubation
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is a Cryoglobulin?

Cryoglobulins are abnormal proteins found in your blood that can clump together when exposed to cold temperatures. These clumps may block small blood vessels, leading to pain, swelling, or other symptoms. They can also trigger inflammation in your body.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like cold sensitivity, joint pain, skin rashes, fatigue, or unexplained fevers. It’s also used to diagnose conditions such as vasculitis, infections (like hepatitis), or certain types of lymphoma.

How Is the Test Performed?

A small blood sample is drawn from a vein in your arm. The blood is then tested in a lab to detect the presence of cryoglobulins by observing how they clump when cooled.

What Are Possible Results?

A positive result means cryoglobulins are present, which may indicate an underlying health issue. A negative result means no obvious clumping was detected, but further testing may still be needed depending on your symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Cryoglobulin Screen

Frequently asked questions

What does a positive result mean?
A positive result suggests you may have a condition like mixed cryoglobulinemia, an autoimmune disorder, or an infection (e.g., hepatitis B or C). Your doctor will work with you to determine the exact cause and next steps, which may include additional tests or treatments.
What if my results are normal but I still have symptoms?
Even if your initial cryoglobulin test is negative, your doctor might recommend follow-up tests or further evaluation to rule out other conditions causing your symptoms. Some conditions can take time to develop, so monitoring may be necessary.
How long does it take to get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will contact you once they are ready to discuss the findings.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy