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Cryoglobulin Profile with Dilution Testing (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures proteins in your blood that thicken (gel) when cooled, which can indicate certain immune system conditions.

Quick summary

["Tests for abnormal proteins that may cause blood vessel issues or symptoms like fatigue or swelling."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
70970-9
Short code
Cryoglob Ser Ql Hypotonic dilution
Synonyms
Cryoglob Ser Ql Hypotonic dilution
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
1.5
Ref high
9
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
hypotonic-dilution
CPT
83002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like joint pain, skin rashes, fatigue, or unexplained swelling. It may also be used to diagnose or monitor conditions such as vasculitis, infections, or certain cancers that affect the immune system.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The process takes about 5 minutes, and you may feel a brief pinch. Bring any medications or supplements you’re taking to discuss with your provider.

What the Test Measures

The test identifies cryoglobulins—proteins that form clumps in cold temperatures. The dilution portion helps determine their concentration and whether they’re stable or break down when warmed, which can help diagnose conditions like mixed cryoglobulinemia.

Possible Conditions Linked to Cryoglobulins

High levels of cryoglobulins may signal immune-related disorders, such as vasculitis (inflammation of blood vessels), chronic infections (e.g., hepatitis), or certain lymphoproliferative diseases. They can also cause symptoms like numbness, skin ulcers, or kidney problems.

Reference range

Follicular: 1.5-9.0 mIU/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cryoglobulin Screen/Dilution

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will discuss findings with you during your follow-up visit.
What does a positive cryoglobulin test mean?
A positive result suggests abnormal proteins may be affecting your blood vessels or immune system. Your doctor will interpret results alongside your symptoms and may recommend additional tests (e.g., blood cultures, imaging) to determine the cause.
Can diet or medications affect cryoglobulin levels?
While diet or some medications (e.g., certain immunosuppressants) *may* influence immune function indirectly, they rarely directly alter cryoglobulin levels. Always discuss any changes with your provider before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy