Serum Protein Electrophoresis (Cryoglobulin Profile)
This test measures proteins in your blood that may form clumps (cryoglobulins) when exposed to cooler temperatures. These clumps can cause problems in blood flow and may indicate underlying conditions like certain infections or autoimmune diseases.
["Cryoglobulins can block blood vessels and may lead to symptoms like fatigue, skin changes, or organ damage—this test helps identify potential risks early."]
Key facts at a glance
- LOINC
- 24038-2
- Short code
- Cryoglob Typ Ser Elph
- Synonyms
- Cryoglob Typ Ser Elph
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 7.35
- Ref high
- 7.45
- Critical range
- 7.2 N/A – 7.6 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- electrophoresis
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is a Cryoglobulin Profile Used For?
Cryoglobulins are proteins that can form sticky clumps in your blood, especially when temperatures drop. This test helps doctors check for these clumps, which can occur in conditions like chronic infections (e.g., hepatitis), certain autoimmune diseases, or lymphoproliferative disorders. It may also be used to monitor treatment progress if you’ve already been diagnosed with a condition linked to cryoglobulins.
Why Might You Need This Test?
Your doctor may order this test if you have symptoms like cold sensitivity, skin rashes, joint pain, or unexplained fatigue. It could also be part of a broader evaluation for conditions like vasculitis, lymphoma, or chronic infections affecting your immune system.
How Is the Test Performed?
A blood sample is drawn from a vein in your arm. The blood is then separated into components, and the protein layer is analyzed using electrophoresis to detect abnormal clumping patterns. This process helps identify whether cryoglobulins are present and, if so, what types.
What Do Results Mean?
Results show whether cryoglobulins are present in your serum. If they are, further testing (like immunofixation) may be needed to determine their cause and type. High levels or abnormal patterns can signal underlying health concerns that require additional medical attention.
Reference range
NCBI: pH 7.35-7.45N/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Cryoglobulin Screen
Frequently asked questions
What are the normal results for this test?
Can cryoglobulins be treated?
How often should I get this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy