Skip to content

Cerebrospinal Fluid Cell Count (with Differential)

Published: August 9, 2026Updated: August 16, 2026

This test measures the number of cells in your cerebrospinal fluid (CSF), including white blood cells and red blood cells, along with the breakdown of white blood cells (differential count). It helps assess conditions affecting the brain and spinal cord.

Quick summary

["A CSF cell count helps diagnose infections, inflammation, or bleeding in the central nervous system."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
24932-6
Short code
CT C-spine
Synonyms
CT C-spine
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your CSF is a clear fluid that surrounds your brain and spinal cord. When there’s an issue—like an infection, injury, or disease—it can change how many cells are present. This test helps doctors identify problems early.

What to Expect Before the Test

You’ll have a small needle inserted into your back to collect a tiny sample of CSF. It’s usually done in a hospital or clinic and may cause mild discomfort, but it’s quick and painless.

Common Conditions This Test Helps Diagnose

High cell counts may signal infections (like meningitis), bleeding (like subarachnoid hemorrhage), or inflammatory diseases (like multiple sclerosis). Low counts might indicate normal pressure or rare conditions.

How the Results Are Used

Doctors compare your results to standard ranges and your symptoms. For example, a high white blood cell count often points to infection, while red blood cells could mean bleeding.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Cell Count

Frequently asked questions

What does a high or low cell count mean?
A high cell count often suggests an infection (like bacterial or viral meningitis), inflammation, or bleeding. A low count may indicate normal findings or rare conditions, but doctors will consider your symptoms and other tests.
How often should I get this test?
Your doctor will determine how often you need this test based on your symptoms, medical history, and diagnosis. It’s usually done as part of a specific evaluation, not routinely.
Is there anything I should avoid before the test?
No special preparations are needed, but inform your doctor if you’re on blood thinners or have a history of bleeding disorders, as this may affect the procedure.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy