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C-reactive protein (high-sensitivity) concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when inflammation is present, often used to assess low-grade inflammation or risk of future health issues.

Quick summary

["hs-CRP helps track subtle inflammation that may not show other symptoms."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36090-9
Short code
CT Extr Ltd
Synonyms
CT Extr Ltd
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hs-CRP Used For?

hs-CRP (high-sensitivity C-reactive protein) is typically ordered to evaluate the risk of cardiovascular disease, monitor chronic inflammatory conditions, or assess response to treatment in conditions like arthritis or infections. It can also be used in screening for certain health risks when other tests are inconclusive.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed using a sensitive immunoassay method to detect very small amounts of hs-CRP.

What Does a High or Low Result Mean?

Results are not interpreted alone—they are compared to your overall health and medical history. Higher levels may indicate increased inflammation or risk for conditions like heart disease, while lower levels suggest reduced inflammation. Your doctor will discuss findings in the context of your specific situation.

Common Reasons for Testing

Your doctor may recommend hs-CRP testing if you have risk factors for heart disease, such as high blood pressure or diabetes, or if you have symptoms of inflammation. It can also be used periodically to monitor chronic conditions or after treatment begins.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

hs-CRP is a marker for systemic inflammation, which can contribute to chronic diseases like atherosclerosis (hardening of arteries). While not a definitive diagnostic tool, it helps guide preventive care, treatment plans, and decisions about lifestyle changes or medications.

Short name

hs-CRP

Frequently asked questions

Why might my hs-CRP test be ordered?
Your doctor may order this test to check for signs of inflammation, assess cardiovascular risk, or monitor conditions like rheumatoid arthritis, lupus, or other inflammatory diseases. It can also be used in research or follow-up care for patients with known health risks.
What does it mean if my hs-CRP is elevated?
An elevated hs-CRP level suggests inflammation is present in your body. This could be due to infection, an autoimmune condition, or other health issues. Your doctor will review your results alongside other tests and symptoms to determine the next steps.
Can lifestyle changes affect hs-CRP levels?
Yes, lifestyle factors like diet, exercise, weight management, and smoking status can influence inflammation levels. Small, sustainable changes—such as eating a heart-healthy diet, staying active, and avoiding smoking—may help lower hs-CRP over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy