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Published: August 9, 2026Updated: August 16, 2026

A blood test that detects IgG antibodies against Colorado tick fever virus to determine past infection or immunity.

Quick summary

{"Detects IgG antibodies indicating previous Colorado tick fever infection","Helps confirm past exposure to the virus transmitted by ticks","Not typically used for acute diagnosis - IgM test is preferred for active infection","Positive result suggests immunity to the virus","Sample is collected from blood (serum)"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16121-6
Short code
CTF IgG
Synonyms
CTFV IgG Titr Ser
Category
cardiac
Sample
serum
Container
Serum separator tube (SST) or red top tube
Units
N/A
Ref low
8
Ref high
16
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Immunofluorescence Assay (IFA) or Enzyme-Linked Immunosorbent Assay (ELISA)
CPT
86635
SNOMED
371949004
Specimen volume
1-2 mL serum minimum
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 72 hours; Frozen (-20°C or below): several weeks
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
72–168 hours
Order
routine

What is this test?

The Colorado Tick Fever Virus IgG Antibody Test is a blood test that detects IgG antibodies in your serum. IgG antibodies are produced by your immune system after exposure to the Colorado tick fever virus, which is transmitted through the bite of an infected tick (Dermacentor andersoni). This test helps determine if you have had a previous infection with the virus.

Why is this test performed?

This test is typically ordered to confirm whether a person has been previously infected with Colorado tick fever, especially in areas where the disease is common (primarily the western United States). It may also be used in epidemiological studies to understand the prevalence of the infection in a population.

What do the results mean?

A positive IgG result indicates that you have been infected with Colorado tick fever virus at some point in the past and likely have developed immunity. A negative result means no previous infection has been detected, though this could also mean the infection was very recent and antibodies haven't developed yet, or the infection occurred so long ago that antibody levels have declined.

How is the test performed?

A healthcare professional will draw a small blood sample from a vein in your arm. The blood is then sent to a laboratory where it is analyzed to detect the presence of IgG antibodies against Colorado tick fever virus. No special preparation is typically required before this test.

Reference range

Negative: <1:8 titer; Equivocal: 1:8-1:16 titer; Positive: >1:16 titer (may vary by laboratory)N/A

Specimen: serum

No special preparation required. Inform laboratory of recent tick exposure or travel to endemic areas.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Is this test used to diagnose an active infection?
No, this test detects IgG antibodies which indicate past infection. For diagnosing active infection, an IgM antibody test or PCR test is typically more appropriate as they can detect the virus or early immune response.
Do I need to fast before this test?
No, fasting is not typically required for this test. You can eat and drink normally before having your blood drawn.
How long does it take to get results?
Results typically take 2-5 days, depending on the laboratory. Your healthcare provider will contact you with the results once they are available.
Is the test safe?
The test involves a routine blood draw, which is generally safe. Some people may experience minor bruising or soreness at the puncture site. Serious complications are rare.
What should I do if my result is positive?
A positive result indicates past exposure and likely immunity. However, you should discuss your results with your healthcare provider who can interpret them in the context of your symptoms and medical history.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy