Skip to content

Ctfvigmtitrser

Published: August 9, 2026Updated: August 10, 2026

This blood test detects IgM antibodies against Colorado tick fever virus, which is transmitted by ticks in the western United States.

Quick summary

{"Colorado tick fever is a viral infection spread by tick bites, primarily in the western U.S.","The IgM test detects early immune response, indicating recent infection","Symptoms include fever, headache, muscle pain, and sometimes rash","Most cases resolve within 2 weeks with rest and supportive care","Prevention focuses on avoiding tick bites in endemic areas"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 10, 2026Editorial policy

Key facts at a glance

LOINC
16122-4
Short code
CTFV-IgM
Synonyms
CTFV IgM Titr Ser
Category
cardiac
Sample
serum
Container
Serum separator tube (SST, gold top) or plain red top tube
Units
N/A
Ref low
8
Ref high
16
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
Enzyme-linked immunosorbent assay (ELISA) for detection of Colorado tick fever virus-specific IgM antibodies using immunocapture or indirect immunoassay techniques
CPT
86635
SNOMED
371949004
Specimen volume
1-2 mL of serum minimum; 2-3 mL preferred
Stability
Room temperature: 24-48 hours; Refrigerated (2-8°C): 5-7 days; Frozen (-20°C or below): several weeks to months. Avoid repeated freeze-thaw cycles.
Hemolysis max
50
Lipemia max
40
Icterus max
20
TAT
48–168 hours
Order
routine

What is this test?

The Colorado tick fever virus IgM antibody test is a blood test that looks for IgM antibodies in your blood. IgM antibodies are the first type of antibodies your immune system produces when fighting a new infection. Their presence indicates that your body is responding to a recent infection with Colorado tick fever virus.

What is Colorado tick fever?

Colorado tick fever is a viral disease caused by the Colorado tick fever virus, a type of coltivirus. It is transmitted through the bite of infected Dermacentor andersoni ticks (Rocky Mountain wood ticks). This disease is primarily found in the western United States, especially in mountainous areas of Colorado, Utah, Wyoming, Montana, and Idaho.

Why might I need this test?

Your healthcare provider may order this test if you have symptoms of Colorado tick fever, especially if you have recently been in an area where tick-borne diseases are common. Common symptoms include sudden high fever, severe headache, muscle aches (myalgia), fatigue, and sometimes a rash. Symptoms typically appear 1-14 days after a tick bite.

How is the test performed?

A healthcare professional will draw a small blood sample from a vein in your arm. This sample is then sent to a laboratory for analysis. The test measures the level of IgM antibodies against Colorado tick fever virus in your serum. Results are typically available within a few days to a week.

What do the results mean?

A positive IgM result suggests a recent or current infection with Colorado tick fever virus. A negative result may mean you do not have the infection, or the infection is too early for detectable antibody levels. Your healthcare provider will interpret your results in combination with your symptoms, exposure history, and possibly other tests.

How is Colorado tick fever treated?

There is no specific antiviral treatment for Colorado tick fever. Most cases are mild and resolve on their own within 2 weeks. Treatment is primarily supportive and includes rest, plenty of fluids, and over-the-counter medications to reduce fever and relieve pain. In severe cases, hospitalization may be required for intravenous fluids and monitoring.

How can I prevent Colorado tick fever?

Prevention focuses on avoiding tick bites when spending time in endemic areas. Use insect repellent containing DEET on skin and clothing, perform regular tick checks after outdoor activities, wear long sleeves and pants in wooded or grassy areas, and promptly remove any attached ticks using fine-tipped tweezers.

Reference range

Negative: <1:8 titer; Equivocal: 1:8 to 1:16 titer; Positive: ≥1:16 titer. Titers may also be reported as relative units or index values with lab-specific cutoffs.N/A

Specimen: serum

No special preparation required. Routine venipuncture procedure. Inform laboratory of recent tick exposure or travel to endemic areas.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings2

Frequently asked questions

How long after a tick bite do symptoms appear?
Symptoms of Colorado tick fever typically appear 1 to 14 days after being bitten by an infected tick, with an average incubation period of 3-6 days.
Is Colorado tick fever contagious?
No, Colorado tick fever is not transmitted person-to-person. It can only be contracted through the bite of an infected tick.
Can I get Colorado tick fever more than once?
Most people who recover from Colorado tick fever develop immunity and are protected from future infections.
Do I need to see a doctor if I find a tick on me?
If you develop fever, headache, muscle aches, or other symptoms within two weeks after finding a tick on you, you should contact your healthcare provider and mention the tick exposure.
What is the difference between IgM and IgG antibodies?
IgM antibodies are produced first during an infection and indicate a recent or current infection. IgG antibodies develop later and provide long-term immunity. Your body may continue to produce IgG antibodies long after the infection has resolved.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy