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Adrenal Fluid (e.g., CSF or other body fluid) Analysis for Cortisol and Related Metabolites via Guided Technique

Published: August 9, 2026Updated: August 16, 2026

This test measures cortisol and its metabolites in a body fluid (such as cerebrospinal fluid) to assess adrenal function or detect abnormalities in hormone metabolism.

Quick summary

["Helps evaluate conditions affecting cortisol production or distribution in specialized fluids like CSF."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
44108-9
Short code
CT Guided Adrenal FNA
Synonyms
CT Guided Adrenal FNA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
136
Ref high
145
Critical range
120 N/A – 160 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
CPT
84295
SNOMED
110741000
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like unexplained headaches, hormonal imbalances, or suspected adrenal dysfunction. It could also be used to investigate rare metabolic or neurological conditions linked to cortisol or its breakdown products in specific fluids.

What to Expect Before the Test

The procedure involves collecting a sample of cerebrospinal fluid (CSF) through a spinal tap or similar guided technique. You may experience mild discomfort, but sedation or anesthesia might be used depending on the complexity. Avoid alcohol or certain medications before the procedure as instructed by your healthcare provider.

What the Test Measures

Cortisol is a hormone produced by the adrenal glands that helps regulate stress responses and metabolism. This test measures cortisol and its metabolites in the fluid, which can provide insights into how cortisol behaves in specific body environments beyond blood or urine.

Common Conditions This Test Helps Diagnose

Conditions like congenital adrenal hyperplasia (CAH), cortisol resistance syndromes, or other metabolic disorders affecting cortisol metabolism may be identified through abnormal cortisol or metabolite levels in CSF. It can also help rule out conditions causing unusual cortisol patterns in non-traditional fluids.

Reference range

Adult: 136-145 mmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Cortisol/Metabolite Profile (CSF-guided)

Frequently asked questions

How might my cortisol levels in this fluid differ from what’s found in blood or urine?
Cortisol levels in cerebrospinal fluid (or other body fluids) can differ significantly from blood due to unique transport mechanisms, binding proteins, or metabolic processing. For example, cortisol may be more concentrated or fragmented differently in CSF compared to plasma, which can affect interpretation. Your doctor will consider the fluid type and clinical context when evaluating results.
What does a high or low cortisol level in this fluid mean?
High cortisol levels in CSF might suggest conditions like pituitary tumors, certain infections, or abnormal cortisol transport. Low levels could indicate adrenal insufficiency, cortisol resistance, or metabolic disorders. However, results must be interpreted alongside clinical symptoms, other test results, and patient history.
Is this test painful or invasive?
The procedure involves inserting a needle into your spine to collect CSF, which can cause mild discomfort. You may feel pressure or a slight ache, but pain is usually manageable. Local anesthesia is often used to minimize discomfort. Recovery is typically quick, but you may experience mild headaches or soreness afterward.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy