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CT-Guided Biopsy, With or Without Intravenous Contrast

Published: August 9, 2026Updated: August 16, 2026

A CT-guided biopsy uses CT imaging to help obtain a tissue sample for examination. Intravenous contrast may be used to guide the procedure.

Quick summary

["This image-guided procedure collects tissue so a pathologist can check for disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46289-5
Short code
CT Guided Bx--WO+W contr IV
Synonyms
CT Guided Bx--WO+W contr IV
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

A CT-guided biopsy is a minimally invasive procedure in which CT scans help a clinician locate the area to be sampled and guide a needle to collect tissue. The tissue is then examined in a laboratory for conditions such as infection, inflammation, or cancer.

Why might I need this test?

A biopsy may be recommended when an imaging study shows a suspicious or unexplained mass, swelling, or abnormal tissue. It can help determine what is causing the finding and whether further treatment is needed.

How is the test performed?

You will usually lie on a CT table while the clinician identifies the biopsy site using images. The area is numbed, a small incision may be made, and a biopsy needle is guided to collect tissue. Intravenous contrast may be given, and sedation may be used depending on the procedure and your comfort needs.

How do I prepare for the test?

Follow the instructions provided by the imaging center, which may include fasting or medication restrictions. Tell the care team about allergies to contrast dye, pregnancy, kidney disease, bleeding disorders, and the use of blood thinners before the procedure. Do not stop any medication unless your clinician specifically instructs you to do so.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Biopsy results may show no significant abnormality, a benign process, inflammation, infection, or abnormal cells that may indicate cancer. Results are interpreted by a pathologist in combination with your symptoms, imaging findings, and other laboratory tests. If additional testing is needed, your clinician will explain the next steps.

Short name

CT-guided biopsy

Frequently asked questions

Is a CT-guided biopsy painful?
The area is usually numbed before the needle is inserted, so you may feel pressure or brief discomfort. Sedation may be offered for some procedures.
Will I receive intravenous contrast?
Contrast may be used to improve the images and guide the biopsy, depending on the procedure. The care team will explain whether it will be administered and check for any contrast allergy beforehand.
How soon are the biopsy results available?
Processing time varies by the type of tissue and tests performed. Your clinician will generally provide the results and explain them during a follow-up discussion.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy