Skip to content

Creatinine Clearance (from Urine and Blood)

Published: August 9, 2026Updated: August 16, 2026

This test measures how well your kidneys filter waste products from your blood, using both your urine and blood samples. It helps assess kidney function and blood flow to the kidneys.

Quick summary

["This test helps doctors check how well your kidneys are working and identify potential kidney problems early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
35917-4
Short code
CT Guided GB Drain+cath place
Synonyms
CT Guided GB Drain+cath place
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms of kidney disease, such as swelling, fatigue, or changes in urine output. It’s also used to monitor kidney function in people with diabetes, high blood pressure, or other health conditions that can affect the kidneys.

How the Test Works

Blood and urine samples are collected. Blood creatinine levels are measured to determine how much waste your kidneys remove, while urine creatinine and volume are measured to calculate how efficiently your kidneys filter blood.

Sample Collection

You’ll need to provide a 24-hour urine sample (collecting all urine over 24 hours) and a blood sample. Follow your doctor’s instructions carefully to ensure accurate results.

What to Expect

The blood draw is quick and usually done in a clinic or doctor’s office. The 24-hour urine collection requires collecting all urine for a full day, which may require planning around your schedule.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Low creatinine clearance may indicate kidney damage, poor blood flow to the kidneys, or other health issues. High values could suggest dehydration or other conditions affecting kidney function. This test is critical for diagnosing and managing chronic kidney disease, kidney stones, or other kidney-related disorders.

Short name

Urine Creatinine Clearance

Frequently asked questions

How long does it take to get results?
Results are typically available within 1 to 3 business days, depending on your lab’s processing time.
What does a low or high creatinine clearance mean?
A low creatinine clearance suggests your kidneys may not be filtering blood as well as they should, which could signal kidney disease or reduced blood flow. A high value may indicate dehydration or other conditions that temporarily increase kidney workload.
Can I eat or drink anything before this test?
For the 24-hour urine collection, you should drink enough fluids to produce about 600–800 mL (about 2–3 cups) of urine per hour. Avoid excessive alcohol or caffeine, which can affect results. For the blood draw, no special preparation is needed unless instructed otherwise.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy