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Kidney Function with Urine Protein-to-Creatinine Ratio (24-Hour Collection) – Quantitative

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of protein and creatinine in your urine over 24 hours to help assess kidney function and detect early kidney damage, such as proteinuria (excess protein in urine).

Quick summary

["This test helps monitor kidney health by checking for protein loss in urine, which can signal kidney issues early."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88325-6
Short code
CT Guided Kidney-L Bx
Synonyms
CT Guided Kidney-L Bx
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like swelling, frequent urination, or blood in urine. It’s also used to monitor kidney disease progression, especially in conditions like diabetes or high blood pressure.

What to Expect Before the Test

You’ll collect all urine for 24 hours in a special container. Drink plenty of water but avoid foods that may affect urine color (like beets or berries). Report any changes in urine volume or symptoms to your doctor.

What Happens During the Test

No special preparation is needed beyond the 24-hour urine collection. The lab analyzes the urine sample for protein and creatinine levels to calculate the ratio.

What the Results Mean

Higher-than-normal protein levels in urine may indicate kidney damage or disease. Your doctor will interpret results in the context of your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

24-Hour Urine Protein-to-Creatinine Ratio

Frequently asked questions

What does a high protein-to-creatinine ratio in urine mean?
A high ratio suggests proteinuria, which may indicate kidney damage, inflammation, or conditions like diabetes or glomerulonephritis. It’s not always a sign of kidney failure but warrants further evaluation.
How often should I get this test?
Your doctor will determine frequency based on your medical history, symptoms, and kidney health. Regular monitoring may be needed if you have chronic kidney disease or risk factors like diabetes or hypertension.
Can diet affect this test?
Yes, certain foods (e.g., salt, protein-rich foods) or medications may influence urine protein levels. Follow your doctor’s instructions to avoid dietary restrictions unless specified.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy