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CT-Guided Liver Biopsy Without Contrast

Published: August 9, 2026Updated: August 16, 2026

A CT-guided biopsy uses imaging to help obtain a small liver sample for examination, without intravenous contrast dye.

Quick summary

["This test provides a liver tissue sample that can help evaluate inflammation, scarring, infection, or other liver abnormalities."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
69092-5
Short code
CT Guided Liver Bx--WO contr
Synonyms
CT Guided Liver Bx--WO contr
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

A CT-guided liver biopsy is a minimally invasive procedure in which a needle is guided into the liver using CT images. A small tissue sample is removed and examined under a microscope. The “without contrast” designation means that intravenous contrast dye is not used.

Why might I need this test?

This test may be recommended when blood tests, imaging, or other findings suggest unexplained liver disease, persistent liver injury, suspected scarring, or a possible mass. The tissue sample can provide more specific information than imaging or blood tests alone.

How is the test performed?

You will usually lie on a CT scanner table while the procedure team identifies a safe site and numbs the skin. A thin biopsy needle is inserted with CT guidance to collect tissue. The sample is then sent to a pathologist for examination, and a bandage is placed over the site.

How do I prepare for the test?

Follow the instructions from your healthcare team, including any fasting requirements and instructions about medications. You may receive local anesthetic and possibly a sedative. Arrange transportation home if sedation is used, and tell the team about allergies, bleeding problems, anticoagulant use, or pregnancy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Biopsy results may show inflammation, liver cell injury, fibrosis or cirrhosis, infection, fat accumulation, or abnormal cells that could indicate cancer. Results must be interpreted with your symptoms, examination, laboratory tests, and imaging because a small sample may not represent the entire liver.

Short name

CT-guided liver biopsy

Frequently asked questions

Is this the same as a liver biopsy done through the skin?
Yes. It is a percutaneous liver biopsy, meaning the needle is inserted through the skin with CT guidance. A different biopsy method may be used if a particular area of the liver is difficult to reach or if there is another reason to avoid this approach.
Will I need contrast dye?
No. This procedure is identified as being performed without intravenous contrast. The CT images are used to guide needle placement without giving contrast dye.
What should I do after the biopsy?
Follow the aftercare instructions, including how long to keep the site clean and when to seek urgent help. Seek prompt care for heavy bleeding, worsening abdominal pain, dizziness or fainting, fever, or difficulty breathing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy