Comprehensive Immunoglobulin Profile (Serum)
This test measures the levels of different types of antibodies (immunoglobulins) in your blood, which help your immune system fight infections and diseases.
["Understanding your antibody levels can help identify immune system function, potential deficiencies, or autoimmune conditions."]
Key facts at a glance
- LOINC
- 42284-0
- Short code
- CT Guided Pl space Absc drn+CT place
- Synonyms
- CT Guided Pl space Absc drn+CT place
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0
- Ref high
- 5
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ct
- CPT
- 82378
- SNOMED
- 394995008
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Immunoglobulins Matter in Your Body
Immunoglobulins (Ig) are proteins produced by your immune system to protect against bacteria, viruses, and other foreign invaders. They include IgG, IgA, and IgM, each serving distinct roles in immunity. Low levels may indicate immune disorders, while high levels could suggest chronic infections or autoimmune conditions.
Types of Immunoglobulins Measured
IgG is the most abundant antibody, providing long-term immunity. IgA protects mucosal surfaces (like your lungs and digestive tract). IgM is the first antibody produced in response to new infections. Together, these help tailor your immune response to specific threats.
When This Test Is Ordered
Your doctor may recommend this test if you have frequent infections, unexplained fatigue, recurrent sinus or ear infections, or symptoms of autoimmune diseases like lupus or rheumatoid arthritis. It may also be part of a routine checkup for individuals with known immune system concerns.
What to Expect Before the Test
No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. The process takes about 5 minutes, and you can resume normal activities afterward. If you’re on blood thinners, inform your healthcare provider before the test.
Reference range
Non-smokers: <2.5 ng/mL; Smokers: <5.0 ng/mLN/A
No special preparation required. For PSA, avoid sexual activity for 24-48 hours before the test.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
IgG, IgA, IgM, and Total Immunoglobulin Levels
Frequently asked questions
How long will it take to get my results?
Can I eat or drink before this test?
Will I feel any pain during the blood draw?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy