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Cerebrospinal Fluid (CSF) Protein Profile (Posterior Fossa Fluid)

Published: August 9, 2026Updated: August 16, 2026

This test measures the protein content in cerebrospinal fluid, which is the fluid surrounding your brain and spinal cord. Proteins in CSF can help identify issues like inflammation, infections, or blood leaks in the brain.

Quick summary

["Protein levels in CSF may indicate underlying neurological conditions or damage to the brain’s protective barrier."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36055-2
Short code
CT Post fossa
Synonyms
CT Post fossa
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like severe headaches, neurological problems (such as weakness, numbness, or vision changes), or if they suspect conditions like meningitis, brain tumors, or bleeding in the brain. It helps assess the health of the fluid protecting your brain and spinal cord.

What to Expect Before the Test

You’ll likely have a small needle inserted into your back to collect a sample of CSF. This is usually done in a hospital or clinic setting. You may feel mild pressure afterward, but it’s generally quick and painless.

What the Results Mean

High protein levels in CSF might suggest inflammation, infection, or blood leakage. Low levels could indicate normal fluid composition or rare conditions. Your doctor will interpret results in relation to your symptoms and medical history.

Common Conditions Affecting Results

Conditions like multiple sclerosis, brain tumors, or traumatic brain injury can alter CSF protein levels. Infections (e.g., meningitis) or bleeding in the brain may also change these readings.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Levels

Frequently asked questions

How often will I need this test?
This test is typically done once, but your doctor may repeat it if symptoms or test results suggest ongoing issues. Follow-up depends on your specific diagnosis and treatment plan.
What does a normal range mean for me?
A normal range doesn’t mean your CSF is completely healthy—it just means your protein levels fall within the expected range for most people. Your doctor will compare your results to your symptoms and other tests.
Can I eat or drink before this test?
You can eat and drink normally before this test unless your doctor advises otherwise. No special preparation is needed, but avoid heavy exercise or caffeine before the procedure.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy