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Serum or Plasma Haptoglobin Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of haptoglobin in your blood, a protein that helps remove harmful substances like free hemoglobin from circulation.

Quick summary

["Haptoglobin helps protect your body and may indicate blood breakdown or certain health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14468-3
Short code
C trach Ag Bld Ql IA
Synonyms
C trach Ag Bld Ql IA
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like hemolysis (destruction of red blood cells), blood disorders, or to monitor treatments affecting red blood cells. It can also help diagnose or evaluate conditions such as autoimmune diseases or infections.

What Does a Low or High Level Mean?

Low haptoglobin levels often suggest red blood cell destruction (hemolysis), which can occur due to infections, autoimmune disorders, or certain medications. High levels may indicate chronic inflammation or other underlying health issues, though this is less common.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then sent to a lab where haptoglobin levels are measured using a specialized analytical method, often an immunoassay or nephelometry technique.

What Are Common Causes of Abnormal Results?

Abnormal haptoglobin levels can result from conditions like sickle cell disease, malaria, autoimmune hemolytic anemia, or severe infections. Medications, liver disease, or certain genetic factors may also play a role.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Haptoglobin plays a role in binding free hemoglobin released during red blood cell destruction, helping to prevent kidney damage and other complications. Low levels may indicate active red blood cell breakdown, prompting further investigation into potential causes like infections, autoimmune disorders, or inherited blood disorders.

Short name

Haptoglobin

Frequently asked questions

What are the normal ranges for haptoglobin?
Normal ranges can vary by lab and method, but typically, haptoglobin levels are measured in milligrams per deciliter (mg/dL). Your results will be compared to your lab’s specific reference range.
Does diet or lifestyle affect haptoglobin levels?
Dietary factors or lifestyle choices like exercise or smoking may indirectly influence red blood cell health, but they do not directly affect haptoglobin levels. Your healthcare provider will consider other factors when interpreting results.
Can haptoglobin levels change over time?
Yes, haptoglobin levels can fluctuate depending on underlying health conditions, treatments, or responses to infections. Regular monitoring may be needed if you have a condition affecting red blood cells or chronic inflammation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy