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Serum or Plasma Alpha-1 Antitrypsin (A1AT) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs and other organs from damage caused by enzymes released during inflammation.

Quick summary

["A1AT levels help assess lung and liver health, especially in conditions like chronic obstructive pulmonary disease (COPD) or genetic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
6352-9
Short code
C trach Ag Stl Ql IF
Synonyms
C trach Ag Stl Ql IF
Category
chemistry
Sample
stool
Container
Clean container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 g
Stability
Refrigerated: 24h, Frozen: 7d
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like persistent cough, shortness of breath, or liver issues. It’s also used to diagnose or monitor conditions like Alpha-1 Antitrypsin Deficiency, a genetic disorder that can affect the lungs and liver over time.

What Does the Result Mean?

Lower than normal levels may indicate a genetic disorder or lung/liver disease, while higher levels might be seen in certain infections, liver diseases, or smoking. Your results will be compared to standard ranges provided by your lab.

Common Conditions Linked to A1AT Levels

Alpha-1 Antitrypsin Deficiency is the most well-known condition affecting A1AT levels. It can lead to chronic lung diseases (like emphysema) or liver cirrhosis. Other conditions, such as chronic obstructive pulmonary disease (COPD) or certain infections, may also influence these levels.

How Is This Test Performed?

A blood sample is drawn from a vein in your arm. The sample is sent to a lab where it’s tested for Alpha-1 Antitrypsin concentration using an immunoassay method. This process typically takes a few days to complete.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Alpha-1 Antitrypsin Deficiency and Beyond

Short name

A1AT Level

Frequently asked questions

What Are My Next Steps If My Results Are Abnormal?
If your A1AT levels are low, your doctor may recommend genetic testing to check for Alpha-1 Antitrypsin Deficiency. If high, further evaluation for liver disease or other conditions may be needed. Follow-up testing or treatments will depend on your symptoms and overall health.
How Often Should I Get This Test?
Your doctor will determine how often you need this test based on your medical history, symptoms, and diagnosis. Regular monitoring may be required if you have a known condition affecting A1AT levels.
Can Diet or Lifestyle Affect My A1AT Levels?
While diet and lifestyle factors like smoking can influence lung health and may indirectly affect A1AT levels, they do not directly alter the protein concentration in your blood. Focus on managing underlying conditions with your healthcare team.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy