Serum or plasma concentration of alpha-1 antitrypsin (A1AT) measured by immunoassay
This test measures the amount of alpha-1 antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation or injury.
["Alpha-1 antitripsin helps prevent lung disease and supports immune function; low levels may indicate genetic risk or liver issues."]
Key facts at a glance
- LOINC
- 14471-7
- Short code
- C trach Ag Vag Ql IA
- Synonyms
- C trach Ag Vag Ql IA
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ia
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test if you have symptoms of lung problems (like chronic bronchitis or emphysema), liver disease, or if you have a family history of alpha-1 antitripsin deficiency. It can also help diagnose or monitor conditions like cirrhosis or certain inflammatory diseases.
What to Expect Before the Test
No special preparation is needed. If you’re having blood drawn, you may feel a slight pinch, but it usually doesn’t cause discomfort. If you’re tested via urine or other fluid, follow any specific instructions your provider gives you.
What the Results Mean
Results are compared to a standard range for healthy individuals. Very low levels may suggest a genetic disorder (like alpha-1 antitripsin deficiency), while very high levels could indicate liver disease or other conditions. Your provider will discuss these findings with you.
Common Conditions Linked to This Test
Low alpha-1 antitripsin levels are most strongly linked to alpha-1 antitripsin deficiency, which can cause lung diseases like emphysema or chronic obstructive pulmonary disease (COPD). It may also be associated with liver diseases like cirrhosis or hepatitis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Abnormal results can signal an underlying health concern that requires further evaluation, such as genetic testing or additional bloodwork to assess liver or lung function. Always discuss your results with your healthcare provider for personalized guidance.
Short name
Alpha-1 Antitrypsin Level
Frequently asked questions
What causes alpha-1 antitripsin levels to be low?
How long does it take to get results from this test?
Can diet or lifestyle changes affect alpha-1 antitripsin levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy