Serum or Plasma Alpha-1 Antitrypsin (A1AT) Concentration

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have a family history of lung diseases like chronic obstructive pulmonary disease (COPD) or emphysema, or if you have symptoms such as shortness of breath, persistent cough, or unexplained lung issues. It may also be checked in people with certain genetic conditions or after exposure to lung-damaging substances.

What to Expect Before the Test

No special preparation is usually needed. You may have a blood sample drawn from a vein in your arm. If you’re having a urine test, you might be asked to collect a sample at home or in a clinic. Avoid smoking or heavy exercise before testing if instructed.

How the Test Works

Blood or plasma is drawn and analyzed using an immunoassay method to measure the protein concentration. Urine samples may be tested similarly, depending on the clinical indication.

Possible Results and Their Meaning

Results are compared to a standard range for healthy individuals. Low levels may suggest genetic disorders (like Alpha-1 Deficiency), while high levels could indicate liver disease or certain inflammatory conditions. Your doctor will interpret results in the context of your health history.