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C-reactive protein (high-sensitivity) concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by the liver in response to inflammation, helping assess low-grade inflammation in the body.

Quick summary

["hs-CRP helps track inflammation, aiding in early detection of conditions like heart disease or autoimmune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
45093-2
Short code
C trach Anal Ql Cult
Synonyms
C trach Anal Ql Cult
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
organism-specific-culture
CPT
86038
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order hs-CRP to monitor chronic conditions like heart disease, rheumatoid arthritis, or other inflammatory diseases. It can also be used to evaluate risk after a heart attack or stroke, or to guide treatment decisions for conditions like lupus or inflammatory bowel disease.

What Does a Result Mean?

Results are not given in absolute numbers but are compared to general reference ranges for healthy adults. Higher levels may indicate ongoing inflammation, while lower levels suggest reduced inflammation. Your doctor will interpret results in the context of your overall health and medical history.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then processed to separate serum or plasma, which is analyzed using a sensitive immunoassay method to measure hs-CRP levels.

What Are Common Causes of Abnormal Results?

Elevated hs-CRP levels can be caused by infections, injuries, certain medications, or underlying inflammatory conditions. Low levels may occur with no significant inflammation but can sometimes be seen in people with very low body fat or certain genetic factors.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

hs-CRP

Frequently asked questions

What does an abnormal hs-CRP result mean for my health?
An elevated hs-CRP result suggests inflammation is present, which may signal an increased risk for cardiovascular disease or other inflammatory conditions. Your doctor will discuss this with you and may recommend lifestyle changes, further testing, or treatment adjustments based on the result.
Can lifestyle changes affect hs-CRP levels?
Yes, lifestyle factors such as diet, exercise, smoking, and stress can influence inflammation levels. Small, sustainable changes like eating a heart-healthy diet, staying physically active, and avoiding smoking may help lower hs-CRP levels over time.
How often should I get this test?
The frequency depends on your medical condition and doctor’s recommendations. Some patients may need hs-CRP testing annually or more often if managing chronic inflammation or cardiovascular risk.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy