Creatinine Clearance (Serum-Based)

What Is Creatinine Clearance Used For?

Creatinine clearance is primarily used to evaluate kidney function and diagnose conditions like chronic kidney disease (CKD). It also helps determine the need for dialysis or other kidney treatments. Doctors may order this test if you have symptoms of kidney problems, such as fatigue, swelling, or frequent infections.

How Is the Test Performed?

To perform this test, you’ll typically provide a blood sample (serum) and a 24-hour urine collection. Blood is drawn to measure creatinine levels, while urine is collected over 24 hours to measure creatinine excretion. Your healthcare provider will guide you on proper urine collection timing and storage.

Why Might You Need This Test?

You may need creatinine clearance testing if you have symptoms of kidney issues, a history of diabetes or high blood pressure (common kidney risk factors), or if your doctor suspects kidney disease. It’s also used before surgeries, during pregnancy, or when monitoring long-term conditions like chronic kidney disease.

What Do Results Mean?

Results are compared to your body size and overall health. Lower than expected values may indicate overhydration or muscle loss, while higher values suggest impaired kidney function. Your doctor will interpret results in the context of your medical history and other test results.