Creatinine Clearance (Serum-Based, 24-Hour Urine Collection)

What Is Creatinine Clearance Used For?

Creatinine clearance is primarily used to evaluate kidney function. It can help diagnose kidney disease, monitor kidney function in patients with chronic conditions (like diabetes or hypertension), and guide treatment decisions for those on dialysis or with kidney-related medications.

How Is the Test Performed?

To perform this test, you’ll need to collect all urine for a full 24-hour period, starting after you wake up the next morning. You’ll also provide a blood sample at the end of the collection period. Your healthcare provider will guide you through the process to ensure accuracy.

What Do the Results Mean?

Results are typically expressed in milliliters per minute (mL/min). Lower than expected values may indicate impaired kidney function, while higher values could suggest overhydration or other conditions. Your doctor will interpret these results in the context of your overall health.

Common Causes of Abnormal Results

Abnormal creatinine clearance results may be caused by kidney disease, dehydration, overhydration, certain medications, or conditions affecting blood flow to the kidneys. Chronic kidney disease, diabetes, or high blood pressure are common underlying causes.