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C-reactive protein (CRP) by nephelometry (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by your liver in response to inflammation, often used to monitor low-level inflammation or infection.

Quick summary

["Helps track subtle inflammation that may not show up on other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
45086-6
Short code
C trach DNA Nph Ql NAA+probe
Synonyms
C trach DNA Nph Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order a high-sensitivity CRP test to check for signs of inflammation in conditions like heart disease, autoimmune disorders, or after surgery. It can also help assess risk for future health problems or monitor treatment effectiveness.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein for a blood draw. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Results are typically reported in milligrams per liter (mg/L). Higher levels may indicate inflammation, infection, or other health concerns. Your doctor will interpret the results in the context of your overall health.

Common Conditions Monitored

This test is often used to evaluate cardiovascular risk, track autoimmune diseases (like rheumatoid arthritis), or monitor healing after trauma or surgery.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: High-sensitivity CRP is a marker for systemic inflammation. While it doesn’t diagnose specific conditions, elevated levels can signal underlying inflammation that may require further investigation or treatment adjustments.

Short name

High-sensitivity CRP

Frequently asked questions

What causes high CRP levels?
Elevated CRP levels can be caused by infections, injuries, autoimmune diseases, or chronic conditions like heart disease. Stress, smoking, or certain medications may also influence results.
Can diet or lifestyle affect CRP levels?
Yes, diet, exercise, and weight management can influence inflammation. Reducing processed foods, increasing omega-3s, and staying active may help lower CRP levels over time.
How often should I get this test?
Your doctor will determine the frequency based on your health needs. Regular monitoring may be recommended if you have a history of inflammation-related conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy