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C-reactive protein (CRP) with high-sensitivity immunoassay (hs-CRP) using a probe-based detection method

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that signals inflammation, often used to check for low-grade inflammation or infection.

Quick summary

["High-sensitivity CRP helps doctors monitor subtle signs of inflammation that may not show up with standard tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49096-1
Short code
C trach DNA Spec NAA+probe-aCnc
Synonyms
C trach DNA Spec NAA+probe-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to assess for early signs of inflammation, such as in cardiovascular disease, autoimmune conditions, or after surgery/injury. It can also help track response to treatments for conditions like arthritis or heart disease.

What Does the Result Mean?

Results are not given in absolute numbers here since reference ranges vary by lab. Instead, they’re often reported as a ratio or qualitative result to indicate levels of inflammation relative to your body’s needs.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. If you’re on blood thinners, let your doctor know before the test.

Common Causes of Elevated CRP

Elevated CRP can occur with infections (like pneumonia), injuries, surgeries, or certain chronic conditions (e.g., rheumatoid arthritis). It may also rise during stress or after exercise.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP (High-Sensitivity C-Reactive Protein)

Frequently asked questions

How often should I get this test?
Your doctor will determine frequency based on your health condition. For example, people with heart disease may check CRP more often than others.
What if my CRP is high?
A high CRP may prompt further testing or adjustments to your treatment plan. Your doctor will discuss next steps with you.
Does diet or exercise affect CRP levels?
Yes, lifestyle factors like diet, exercise, and smoking can influence CRP. Eating anti-inflammatory foods, staying active, and avoiding smoking may help lower CRP levels.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy