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Quantitative Immunoassay for Anti-Double-Stranded DNA Antibodies (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of antibodies that target double-stranded DNA in your blood. It helps identify conditions like lupus (systemic lupus erythematosus) where these antibodies may be present.

Quick summary

["This test helps diagnose autoimmune diseases by detecting unusual immune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43406-8
Short code
C trach+GC DNA Spec Ql Probe+sig amp
Synonyms
C trach+GC DNA Spec Ql Probe+sig amp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-sig
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like joint pain, fatigue, rash, or other signs of lupus or other autoimmune conditions. It can also be used to monitor disease activity in people already diagnosed with these conditions.

What Does a Positive Result Mean?

A positive result suggests an elevated presence of anti-dsDNA antibodies, which may indicate an autoimmune response. However, this alone doesn’t confirm a diagnosis; it’s often used alongside other tests and clinical findings.

Sample Collection and Preparation

Blood is drawn from a vein in your arm, and the sample is processed into serum or plasma for testing. This test is typically performed on fresh or stored serum/plasma samples.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications, especially blood thinners, that you’re taking. Avoid alcohol before the test if instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Anti-dsDNA Antibody Test

Frequently asked questions

What are the normal ranges for this test?
There are no universally standardized reference ranges for anti-dsDNA antibody levels. Results are typically interpreted in the context of your clinical symptoms, other test results, and overall health.
How often should I get this test if I have lupus?
Your healthcare provider will determine the frequency based on your disease activity, symptoms, and response to treatment. Regular monitoring may include periodic testing to track antibody levels and disease progression.
Can lifestyle changes affect my test results?
While lifestyle factors like diet, stress, and exercise can influence overall health, they may not directly impact antibody levels measured in this test. However, managing symptoms and maintaining overall wellness is important for managing autoimmune conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy