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C-reactive protein (CRP) with high-sensitivity measurement (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation, often used to monitor or detect low-grade inflammation or infection.

Quick summary

["hs-CRP helps track inflammation, aiding early detection of conditions like heart disease or autoimmune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90358-3
Short code
C trach+GC pnl Anorectl NAA+probe
Synonyms
C trach+GC pnl Anorectl NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why hs-CRP Matters in Health Monitoring

High-sensitivity CRP (hs-CRP) is a blood test that detects small amounts of a protein called C-reactive protein. CRP is produced by your liver in response to inflammation, which can occur due to infections, injuries, or chronic conditions like arthritis or heart disease. This test is particularly useful because it can identify subtle, long-term inflammation that might not be obvious otherwise.

How the Test Works

Your blood sample is drawn and analyzed using a sensitive immunoassay method to measure CRP levels. The test is designed to pick up very low concentrations of CRP, which is why it’s called high-sensitivity.

Common Uses for hs-CRP

Doctors often use hs-CRP to assess risk for cardiovascular diseases, monitor chronic inflammatory conditions, or evaluate the effectiveness of treatments for conditions like rheumatoid arthritis or other autoimmune diseases.

What Normal Results Mean

While reference ranges can vary by lab, lower CRP levels generally indicate minimal inflammation. Elevated levels may signal inflammation or infection, prompting further investigation. Your doctor will interpret results in the context of your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Inflammation and Disease Risk

Short name

hs-CRP

Frequently asked questions

What does a high hs-CRP level mean?
A high hs-CRP level suggests inflammation is present in your body. This can be due to infections, injuries, or chronic inflammatory diseases. It may also indicate an increased risk of heart disease or other conditions linked to long-term inflammation, helping doctors tailor preventive care or treatment plans.
Can hs-CRP be used to diagnose a specific condition?
hs-CRP is not a standalone diagnostic test for specific conditions like infections or autoimmune diseases. It’s often used alongside other tests to assess risk or monitor inflammation. Your doctor will consider the results together with your symptoms, medical history, and other lab findings.
How often should I get an hs-CRP test?
The frequency of hs-CRP testing depends on your health status and any conditions you have. For example, people at higher risk for heart disease or those with chronic inflammatory conditions may get tested more regularly. Always follow your healthcare provider’s recommendations.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy