Skip to content

C-reactive protein (CRP) measured by nephelometry (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This blood test measures a protein called C-reactive protein, which your body produces in response to inflammation. It helps assess low-level inflammation that may not be obvious from other tests.

Quick summary

["High-sensitivity CRP helps track subtle inflammation, often used alongside other tests for heart disease risk or monitoring conditions like arthritis."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
45005-6
Short code
C trach IgA Ser Ql
Synonyms
C trach IgA Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is High-Sensitivity CRP Used For?

High-sensitivity CRP is primarily used to evaluate the risk of cardiovascular disease. It can also help monitor chronic inflammatory conditions, such as rheumatoid arthritis, or assess responses to treatments that target inflammation.

How Is the Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed using a specialized nephelometry method to measure CRP levels precisely.

Why Might Your Doctor Order This Test?

Your doctor may recommend this test if you have risk factors for heart disease (like high cholesterol or diabetes), if you have symptoms of inflammation, or if you’re being monitored for conditions like arthritis or other chronic inflammatory diseases.

What Do the Results Mean?

Results are interpreted in the context of your overall health. Higher levels may indicate increased inflammation, which could signal a higher risk for heart disease or other inflammatory conditions. Your doctor will discuss these findings with you.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High-sensitivity CRP is a marker for systemic inflammation, often used alongside other tests to assess cardiovascular risk. While it doesn’t diagnose specific conditions, it helps guide treatment decisions and monitor long-term health trends in patients with chronic inflammatory diseases.

Short name

High-sensitivity CRP (hs-CRP)

Frequently asked questions

Why do I need this test if I don’t have obvious symptoms of inflammation?
Even without noticeable symptoms, inflammation can occur silently in your body. High-sensitivity CRP helps detect these low-level inflammatory signals, which may contribute to conditions like heart disease or arthritis over time.
What are the typical reference ranges for this test?
Reference ranges vary by lab and individual health status. Your doctor will provide your specific results and explain what they mean for your situation.
Can lifestyle changes affect my CRP levels?
Yes, lifestyle factors like diet, exercise, smoking, and stress can influence inflammation levels. Small, sustainable changes—such as eating a heart-healthy diet, staying active, and managing stress—may help lower CRP levels over time.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy