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Cerebrospinal fluid (CSF) total protein by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein found in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Protein levels can help identify issues like inflammation, infections, or blood leaks in the central nervous system.

Quick summary

["Protein in CSF may signal neurological concerns or infections."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43062-9
Short code
C trach IgG Titr CSF
Synonyms
C trach IgG Titr CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82977
SNOMED
3110003
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like headaches, neck stiffness, confusion, or neurological problems. It’s also used to diagnose conditions such as meningitis, brain tumors, or multiple sclerosis. Sometimes, it’s part of a routine checkup if you’re at higher risk for certain neurological diseases.

What to Expect Before the Test

You’ll likely have a small needle inserted into your back to collect a sample of CSF. The procedure is quick and usually painless. You may feel a slight pinch, but most people don’t experience significant discomfort. Avoid heavy lifting or strenuous activity for a few hours afterward.

What the Results Mean

Elevated protein levels in CSF can indicate inflammation, infections, or bleeding into the brain/spinal cord. Lower-than-normal levels might suggest certain genetic or metabolic disorders. Your doctor will interpret the results in relation to your symptoms and medical history.

Common Conditions Linked to Abnormal Results

High protein levels may be seen in conditions like meningitis, encephalitis, or multiple sclerosis. Low protein levels can be associated with conditions like cerebral salt-wasting syndrome or certain genetic disorders. Always discuss your results with your healthcare provider.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Protein Level

Frequently asked questions

What causes protein levels in CSF to be higher than usual?
Higher-than-normal protein levels in CSF can result from infections (like meningitis), inflammatory diseases (such as multiple sclerosis), or bleeding into the brain/spinal cord. Your doctor may also check for conditions like tumors or metabolic disorders that affect protein production.
How is this test different from a blood protein test?
This test specifically measures protein in cerebrospinal fluid, which is distinct from blood protein tests. CSF protein reflects what crosses the blood-brain barrier or is produced locally in the brain, while blood tests measure proteins circulating in your bloodstream. Both can be useful but serve different diagnostic purposes.
Can diet or medications affect CSF protein levels?
Dietary changes or most common medications typically do not directly affect CSF protein levels. However, certain medications (like steroids) may influence inflammation-related protein changes. Always ask your doctor about how your medications or lifestyle might impact your test results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy