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Cerebrospinal Fluid Total Protein (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). It helps assess conditions affecting the brain’s protective barrier or blood-brain barrier.

Quick summary

["Protein levels in CSF can indicate issues like inflammation, infection, or bleeding in the brain."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
27185-8
Short code
C trach IgG Titr CSF IF
Synonyms
C trach IgG Titr CSF IF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Ref low
8
Ref high
61
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82977
SNOMED
3110003
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like severe headaches, neurological problems, or signs of conditions such as meningitis, multiple sclerosis, or brain tumors. It’s also used to diagnose or monitor certain spinal or brain disorders.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your back to collect a small amount of CSF, often done under mild sedation. You might feel pressure or a slight ache afterward.

What the Results Mean

Higher-than-normal protein levels may suggest inflammation, infection, or a tumor. Lower-than-normal levels could indicate conditions like Guillain-Barré syndrome or certain genetic disorders. Your doctor will interpret results in the context of your symptoms and medical history.

Common Conditions Monitored

This test helps diagnose or monitor conditions like meningitis, encephalitis, multiple sclerosis, subarachnoid hemorrhage, or certain types of brain tumors. It can also check for blood leaks into the CSF or nerve damage.

Reference range

Adult males: 8-61 U/L; Adult females: 5-36 U/LN/A

Specimen: csf

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Protein in CSF can reflect underlying brain or spinal cord health. Elevated levels often point to inflammation, immune responses, or structural issues, while abnormal patterns may guide treatment decisions.

Short name

CSF Total Protein

Frequently asked questions

What does a high CSF protein level usually mean?
A high protein level in CSF often signals inflammation, infection (like meningitis), or a breakdown of the blood-brain barrier. It may also be seen in conditions such as multiple sclerosis or certain tumors. Your doctor will review your symptoms and other test results to determine the cause.
How is CSF protein tested?
The test involves collecting a small sample of cerebrospinal fluid through a procedure called a lumbar puncture (spinal tap). The fluid is then analyzed in a lab to measure the total protein content.
Can diet or medications affect CSF protein levels?
Dietary factors or common medications typically do not significantly affect CSF protein levels. However, certain medications (like steroids) or conditions (like severe dehydration) might influence results indirectly. Always discuss any concerns with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy