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C-reactive protein (CRP) with high-sensitivity measurement

Published: August 9, 2026Updated: August 16, 2026

This blood test measures a protein produced by your liver in response to inflammation, helping detect low-level inflammation that may not be obvious otherwise.

Quick summary

["hs-CRP helps identify subtle signs of inflammation that could signal underlying health risks."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16596-9
Short code
C trach IgM CSF IF-aCnc
Synonyms
C trach IgM CSF IF-aCnc
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

High-sensitivity C-reactive protein, or hs-CRP, is a substance your liver produces when there is inflammation somewhere in your body. Measuring it with a simple blood test helps your doctor estimate your risk of heart attack, stroke, and other cardiovascular problems, often before any symptoms appear, so prevention steps can start earlier.

hs-CRP is a sensitive marker for inflammation, which can occur even when you don’t feel sick. It’s often used to assess risk for conditions like heart disease or autoimmune disorders, though it’s not a standalone diagnosis tool.

The hs-CRP test is a straightforward blood test. A healthcare professional draws a small sample of blood, usually from a vein in your arm, and sends it to a laboratory. The lab measures the amount of C-reactive protein in the sample and reports the result in mg/L, which your doctor interprets together with your other risk factors.

A small blood sample is taken from your arm and sent to a lab. The test measures the tiny amounts of CRP in your blood, which can indicate inflammation from infections, injuries, or chronic conditions like arthritis or heart disease.

Very little preparation is needed for an hs-CRP test. Fasting is generally not required, but follow any specific instructions from your doctor. Let your care team know about recent infections, injuries, chronic conditions, or medications you take, since illness and inflammation from other causes can temporarily raise your hs-CRP level and affect the result.

No special preparation is needed, but let your healthcare provider know if you’re taking blood thinners or have recent injuries, infections, or surgeries, as these can affect results.

Results are usually grouped by cardiovascular risk: below 1.0 mg/L is considered low, 1.0 to 3.0 mg/L is average, and above 3.0 mg/L suggests higher risk. A high result does not diagnose a specific disease. Your doctor may repeat the test, check other markers, and discuss lifestyle changes, medications, or further testing to protect your heart health.

Results are typically reported in micrograms per milliliter (µg/mL). Higher levels may signal increased inflammation, prompting further evaluation by your doctor. Follow-up may include lifestyle changes, additional tests, or treatment adjustments based on clinical context.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

hs-CRP (High-Sensitivity C-Reactive Protein)

Frequently asked questions

What does a high hs-CRP level mean?
A high hs-CRP level suggests inflammation is present in your body, which can be linked to conditions like cardiovascular disease, certain infections, or inflammatory diseases. However, it’s not definitive on its own—your doctor will consider your overall health and symptoms to interpret results.
Can diet or exercise lower hs-CRP?
Yes! Reducing inflammation often involves lifestyle changes such as eating a heart-healthy diet (rich in fruits, vegetables, and whole grains), staying physically active, managing stress, and avoiding smoking. These changes can help lower CRP levels over time.
Your doctor will determine how often you need hs-CRP testing based on your medical history, symptoms, and risk factors. Some people may get it annually or more frequently if they have conditions like heart disease or autoimmune disorders.
For most adults, hs-CRP is measured once as part of a cardiovascular risk assessment and then repeated every few years, or whenever your doctor wants to reevaluate your risk. If you have an ongoing inflammatory condition or new symptoms, your doctor may recommend more frequent testing tailored to your individual situation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy