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Cerebrospinal Fluid Total Protein with Albumin-to-Globulin Ratio

Published: August 9, 2026Updated: August 16, 2026

This test measures the total protein content in your cerebrospinal fluid (CSF) and compares the ratio of albumin to globulin proteins, which can help assess conditions affecting the brain’s protective barrier or fluid balance.

Quick summary

["This test helps diagnose or monitor conditions like infections, inflammation, or blood leaks in the brain."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110870-3
Short code
C trach IgM Msmt CSF
Synonyms
C trach IgM Msmt CSF
Category
chemistry
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is Cerebrospinal Fluid (CSF)?

Cerebrospinal fluid (CSF) is a clear fluid that surrounds your brain and spinal cord, acting as a cushion and removing waste. It contains proteins, including albumin and globulin, which can change in certain health conditions.

Why Is This Test Done?

Your doctor may order this test to investigate symptoms like headaches, neurological issues, or signs of infection/inflammation in the brain. It can also help diagnose conditions like meningitis, multiple sclerosis, or bleeding into the CSF.

How Is the Test Performed?

A small amount of CSF is collected via a procedure called a lumbar puncture (spinal tap). The sample is then analyzed for protein levels and the albumin-to-globulin ratio using specialized lab techniques.

What Are Common Findings?

Elevated total protein or abnormal ratios may suggest inflammation, infection, or blood leakage. Lower-than-expected levels might indicate certain genetic disorders or overproduction of CSF.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Key Takeaways

Short name

CSF Protein & Alb/Glob Ratio

Frequently asked questions

Will I feel pain during the lumbar puncture?
You may experience mild discomfort or a dull ache at the injection site, but it’s usually short-lived. Numbing medication is used to minimize pain during the procedure.
How soon will I get results?
Results are typically available within 1–3 business days, depending on lab processing times. Your doctor will discuss them with you during a follow-up visit.
Can I drink or eat before the test?
No special preparation is needed, but avoid heavy meals or caffeine 2 hours before the procedure to reduce discomfort.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy