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Chloride ion concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of chloride, a key electrolyte, in your blood plasma or serum. Chloride helps balance fluids and maintain proper nerve and muscle function.

Quick summary

["Chloride levels help assess hydration, kidney function, and acid-base balance in your body."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26668-4
Short code
C trach L1 Ab Ser Ql
Synonyms
C trach L1 Ab Ser Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for conditions like dehydration, kidney disease, or metabolic imbalances. It can also help diagnose or monitor conditions such as low blood sodium (hyponatremia) or high blood potassium (hyperkalemia).

What Does a Low or High Chloride Level Mean?

Low chloride levels might indicate dehydration, vomiting, or certain kidney or liver problems. High chloride levels can suggest dehydration, kidney issues, or conditions like diabetic ketoacidosis.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then sent to a lab to measure chloride concentration using a specialized method.

What Are Common Causes of Abnormal Results?

Changes in chloride levels can be caused by dehydration, excessive sweating, certain medications, kidney or liver disease, or metabolic disorders like acidosis or alkalosis.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Chloride is an essential electrolyte that helps maintain fluid balance, nerve function, and acid-base equilibrium in the body. Abnormal levels can signal underlying health issues requiring medical attention, such as dehydration, kidney dysfunction, or metabolic disorders.

Short name

Serum Chloride

Frequently asked questions

What are the normal reference ranges for this test?
Reference ranges can vary by lab and may not be provided here due to variability. Your results will be compared to your specific lab’s standards and discussed with your healthcare provider.
How often should I get this test?
Your healthcare provider will determine the frequency based on your health status, symptoms, and medical needs. Regular monitoring may be recommended if you have chronic conditions like kidney disease.
Can I eat or drink anything before this test?
Typically, you can eat and drink normally before this test unless instructed otherwise by your provider. Some tests may have specific fasting requirements, but this one does not.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy