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Chloride ion concentration in serum or plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of chloride, a key electrolyte, in your blood. Chloride helps maintain fluid balance and supports nerve and muscle function.

Quick summary

["Chloride levels help doctors check for dehydration, kidney issues, or other health conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90363-3
Short code
C trach L1 IgM Titr Ser IA
Synonyms
C trach L1 IgM Titr Ser IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to diagnose or monitor conditions like dehydration, kidney disease, heart problems, or metabolic imbalances. It’s also used to check for acid-base disorders or to guide treatment for conditions like hyponatremia or hypernatremia.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re on dialysis, your doctor may check chloride levels as part of your routine care.

What the Results Mean

Results are compared to a general reference range, but exact values can vary by lab. Low chloride levels may indicate dehydration, kidney problems, or excessive vomiting/diarrhea. High levels could suggest kidney disease, heart failure, or overuse of certain medications.

Common Conditions Monitored

Chloride levels are often checked alongside sodium, potassium, and other electrolytes to assess overall fluid and electrolyte balance. Conditions like chronic kidney disease, heart failure, or metabolic alkalosis may require monitoring chloride levels.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Chloride

Frequently asked questions

How long will it take to get my results?
Results are typically available within 1–3 business days, depending on your lab. Your doctor will contact you once they’re ready, especially if results are outside normal ranges.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise. Fasting isn’t required for this test.
What if my chloride level is too high or too low?
If your levels are abnormal, your doctor may recommend adjustments to your diet, medications, or treatment plan. They’ll discuss next steps with you based on your specific situation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy