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Chloride ion concentration in serum/plasma (mass concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of chloride, a key electrolyte, in your blood. Chloride helps balance fluids and maintain normal cell function.

Quick summary

["Chloride levels help assess fluid balance and kidney function."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51734-2
Short code
C trach L2 IgA+IgG+IgM Ser-Imp
Synonyms
C trach L2 IgA+IgG+IgM Ser-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions affecting fluid balance, such as dehydration, kidney problems, or heart failure. It can also help diagnose or monitor conditions like metabolic alkalosis or acidosis.

What Does a Result Mean?

Results are compared to standard ranges for your age and health. Low chloride levels may indicate excessive loss of fluids or vomiting, while high levels could suggest dehydration, kidney issues, or certain medical treatments.

Common Conditions Monitored

Chloride levels are often checked alongside sodium, potassium, and bicarbonate to evaluate overall electrolyte balance. Abnormal results may prompt further testing for conditions like hyponatremia, hypernatremia, or metabolic disorders.

Sample Collection and Preparation

A blood sample is taken from a vein, usually in your arm. The sample is processed to separate serum or plasma for testing. Chloride levels are measured using a specialized lab technique, often automated and precise.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Key Role in Electrolyte Balance

Short name

Serum/plasma chloride

Frequently asked questions

What Causes Abnormal Chloride Levels?
Abnormal chloride levels can result from conditions like severe vomiting or diarrhea (leading to low chloride), kidney disease (affecting chloride retention), or certain medications (e.g., diuretics). Chronic conditions like heart failure or liver disease may also influence chloride balance.
How Often Should This Test Be Done?
The frequency depends on your health status. Routine blood tests may include chloride as part of an electrolyte panel, while patients with chronic conditions may need monitoring more often.
What Are the Risks of This Test?
There are minimal risks from a blood draw, such as mild bruising or discomfort at the site. Rarely, allergic reactions to the blood collection process can occur, though this is uncommon.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy