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Chloride ion concentration in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of chloride, a key electrolyte, in your blood. Chloride helps maintain fluid balance and supports nerve and muscle function.

Quick summary

["Chloride levels help doctors assess hydration, kidney function, and acid-base balance in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43175-9
Short code
C trach L2 IgM Titr Ser IF
Synonyms
C trach L2 IgM Titr Ser IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to check for conditions affecting fluid balance, such as dehydration, kidney problems, or disorders like metabolic alkalosis or acidosis. It can also help evaluate the effects of certain medications or treatments.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or vein to draw blood. If you’re concerned about needles, let your healthcare provider know.

What the Results Mean

Chloride levels can vary based on hydration status, diet, and health conditions. Abnormal results may signal issues like dehydration, kidney disease, or imbalances in other electrolytes.

Common Conditions Monitored

High chloride levels might indicate dehydration, kidney problems, or conditions like Cushing’s syndrome. Low levels could suggest overhydration, kidney failure, or certain metabolic disorders.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Chloride is a critical electrolyte that works alongside sodium and bicarbonate to maintain proper fluid balance and acid-base equilibrium in the body. Abnormal levels can signal underlying health issues, such as kidney dysfunction, dehydration, or metabolic imbalances, which may require medical attention.

Short name

Serum Chloride

Frequently asked questions

How long will I need to wait for my results?
Results are typically available within 1–3 business days, depending on your lab. Your healthcare provider will discuss them with you during your follow-up visit.
What does it mean if my chloride level is too high or too low?
High chloride levels may suggest dehydration, kidney issues, or conditions like hypernatremia (high sodium). Low levels could indicate overhydration, kidney failure, or metabolic alkalosis. Your doctor will interpret results in the context of your overall health.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise by your doctor. No fasting is required for this test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy