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Cystatin C Quantitative Measurement (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of cystatin C, a protein produced by all cells in the body. It helps assess kidney function.

Quick summary

["Cystatin C helps evaluate kidney health and may be used alongside other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
57287-5
Short code
C trach rRNA Anal Ql NAA+probe
Synonyms
C trach rRNA Anal Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
CPT
86038
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

This test is done to help your doctor check how well certain parts of your body are working, look for early signs of illness, or monitor a condition you already have. The results give your care team important information for diagnosing problems, guiding treatment decisions, and tracking your overall health over time.

Your doctor may order this test to check how well your kidneys are working. It can also be used to monitor kidney disease progression or guide treatment decisions, especially in people with conditions like chronic kidney disease or certain genetic disorders.

The sample is usually collected by drawing a small amount of blood from a vein in your arm, but depending on the test, it may instead involve a urine sample, a throat or nasal swab, or another simple method. A trained technician will perform the collection, and the process typically takes only a few minutes.

A small amount of blood is drawn from a vein, usually in your arm, by a healthcare professional. The blood sample is sent to a lab for testing.

Your result shows whether your values fall within the normal reference range. A normal result usually means there is no sign of the problem being checked for, while an abnormal result may point to a condition that needs closer attention. Your provider will explain what your specific numbers mean and whether any follow-up testing or treatment is needed.

Higher than expected levels of cystatin C may suggest kidney problems or other conditions affecting kidney function. Lower levels might indicate normal kidney function or certain metabolic conditions. Your doctor will interpret the result in the context of your overall health and medical history.

Common causes of abnormal results include infections, inflammation, dehydration, recent illness, stress, and certain medicines or supplements. Problems with organs such as the kidneys, liver, heart, or thyroid can also affect your values. Your provider will look at your result together with your symptoms and medical history to determine the most likely cause.

Elevated cystatin C levels can be linked to kidney disease, dehydration, muscle disorders, or certain medications. Lower levels might be seen in people with low muscle mass or specific genetic conditions. Always discuss any changes in your results with your healthcare provider.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cystatin C

Frequently asked questions

Your doctor may use cystatin C levels to monitor kidney function, especially in patients with diabetes, hypertension, or a family history of kidney disease. It can also be useful in diagnosing conditions like polycystic kidney disease or assessing the effectiveness of treatments for kidney-related illnesses.
How often you need this test depends on your age, your overall health, your risk factors, and the reason it was ordered. Some people only need it once, while others with ongoing conditions may need it every few months or once a year. Your provider will set the schedule that is right for you.
The frequency of this test depends on your health condition and medical needs. If you have kidney disease, your doctor may recommend testing more often to track changes over time. Ask your healthcare provider for specific instructions tailored to your situation.
It depends on the specific test being done. Many blood tests require fasting for 8 to 12 hours beforehand, which means nothing to eat or drink except water, while other tests need no special preparation at all. Ask your provider or the laboratory ahead of time so your sample can be collected correctly and your results stay accurate.
Typically, you can eat and drink normally before this blood test unless your doctor instructs otherwise. Cystatin C levels are not affected by diet or fasting, so no special preparation is needed.
The most common side effect is a slight bruise, redness, or soreness at the injection site. Rarely, there may be a slight swelling or pain. Most side effects are mild and go away quickly. If you experience any unusual symptoms or signs of infection, contact your healthcare provider.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy