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C-reactive protein (high-sensitivity) concentration, serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when inflammation is present, often used to assess low-grade inflammation or risk of future health issues.

Quick summary

["hs-CRP helps track inflammation and may help identify risks for conditions like heart disease or autoimmune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
36066-9
Short code
CT Should-R
Synonyms
CT Should-R
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.4
Ref high
4
Critical range
0.1 N/A – 20 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ct
CPT
84443
SNOMED
301343003
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is hs-CRP Used For?

hs-CRP is primarily used to monitor chronic, low-level inflammation in the body. Doctors may order it to evaluate risk factors for cardiovascular disease, especially in people with no obvious symptoms of inflammation. It can also help assess the effectiveness of treatments for conditions like arthritis or other inflammatory diseases.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum or plasma, which is sent to a lab for analysis using a sensitive immunoassay method. The test measures the concentration of C-reactive protein, a marker of inflammation.

Why Might You Need This Test?

Your doctor may recommend an hs-CRP test if you have risk factors for heart disease, such as high blood pressure, diabetes, or a family history of heart problems. It may also be used in people with chronic conditions like rheumatoid arthritis or after a heart attack to monitor ongoing inflammation.

What Do Results Mean?

Results are reported in milligrams per liter (mg/L). Higher levels may indicate increased inflammation, which can be linked to higher risks for heart disease or other inflammatory conditions. However, results alone don’t diagnose a condition—they’re often used alongside other tests and clinical findings.

Reference range

Adult: 0.4-4.0 mIU/LN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

What does an elevated hs-CRP level mean?
An elevated hs-CRP level suggests your body is experiencing inflammation, which can be linked to higher risks for heart disease or other inflammatory conditions. It doesn’t diagnose a specific problem but may signal areas your doctor should investigate further.
How often should I get this test?
Your doctor will determine how often you need this test based on your health status, risk factors, and medical history. Some people may need it annually or more frequently if they have chronic conditions or risk factors for heart disease.
Can lifestyle changes affect hs-CRP levels?
Yes, lifestyle changes such as improving diet (e.g., reducing processed foods, increasing fruits/vegetables), exercising regularly, managing stress, and quitting smoking can help lower inflammation and potentially reduce hs-CRP levels over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy