C-reactive protein (high-sensitivity) concentration, serum/plasma
This test measures a protein in your blood that rises when inflammation is present, often used to assess low-grade inflammation or risk of future health issues.
["hs-CRP helps track inflammation and may help identify risks for conditions like heart disease or autoimmune disorders."]
Key facts at a glance
- LOINC
- 36066-9
- Short code
- CT Should-R
- Synonyms
- CT Should-R
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.4
- Ref high
- 4
- Critical range
- 0.1 N/A – 20 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ct
- CPT
- 84443
- SNOMED
- 301343003
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is hs-CRP Used For?
hs-CRP is primarily used to monitor chronic, low-level inflammation in the body. Doctors may order it to evaluate risk factors for cardiovascular disease, especially in people with no obvious symptoms of inflammation. It can also help assess the effectiveness of treatments for conditions like arthritis or other inflammatory diseases.
How Is the Test Performed?
A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum or plasma, which is sent to a lab for analysis using a sensitive immunoassay method. The test measures the concentration of C-reactive protein, a marker of inflammation.
Why Might You Need This Test?
Your doctor may recommend an hs-CRP test if you have risk factors for heart disease, such as high blood pressure, diabetes, or a family history of heart problems. It may also be used in people with chronic conditions like rheumatoid arthritis or after a heart attack to monitor ongoing inflammation.
What Do Results Mean?
Results are reported in milligrams per liter (mg/L). Higher levels may indicate increased inflammation, which can be linked to higher risks for heart disease or other inflammatory conditions. However, results alone don’t diagnose a condition—they’re often used alongside other tests and clinical findings.
Reference range
Adult: 0.4-4.0 mIU/LN/A
Take your thyroid medication after the blood draw if applicable. No fasting required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
hs-CRP
Frequently asked questions
What does an elevated hs-CRP level mean?
How often should I get this test?
Can lifestyle changes affect hs-CRP levels?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy