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Total IgE Antibody Level (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Immunoglobulin E (IgE) antibodies in your blood. IgE is linked to allergic reactions and certain immune responses.

Quick summary

["IgE levels help identify allergies or immune system conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
58025-8
Short code
Cultivated Rye IgE/IgE total %
Synonyms
Cultivated Rye IgE/IgE total %
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does IgE Measure?

IgE (Immunoglobulin E) is a type of antibody produced by your immune system in response to allergens, parasites, or other triggers. High levels may suggest allergies, asthma, or other allergic conditions. Low levels are less commonly evaluated but could indicate certain immune deficiencies.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like sneezing, itching, skin rashes, or breathing difficulties that suggest allergies. It can also help diagnose conditions like allergic asthma, atopic dermatitis, or parasitic infections.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to measure IgE levels. The test typically takes a few days to return results.

What Are Common Results?

Results are reported in units of IgE per milliliter (IU/mL) of blood. Interpretation depends on your symptoms and medical history; elevated levels often indicate allergies or immune-related conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: IgE Levels Play a Key Role in Diagnosing Allergic Reactions and Immune Disorders

Short name

IgE Total

Frequently asked questions

What Does an Elevated IgE Level Mean?
An elevated IgE level may indicate allergies (e.g., to pollen, dust, or foods), asthma, or conditions like chronic urticaria. It does not always mean you have an allergy—your doctor will consider symptoms and other tests.
What If My IgE Level Is Normal?
A normal IgE level doesn’t rule out allergies. Some people with allergies have normal IgE levels, so other tests (like skin prick tests or allergy challenges) may be needed to confirm a diagnosis.
How Often Should I Get This Test?
Your doctor will determine how often to repeat this test based on your symptoms, treatment plan, or ongoing medical conditions. Follow-up may be needed if allergies persist or worsen.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy