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Cerebrospinal Fluid (CSF) Protein Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your cerebrospinal fluid (the fluid surrounding your brain and spinal cord). Protein levels can help identify conditions affecting the central nervous system, such as infections, inflammation, or blood leaks.

Quick summary

["Protein in CSF may signal neurological issues that require further evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
48258-8
Short code
Cultivated Rye LR-mCnc
Synonyms
Cultivated Rye LR-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you have symptoms like headaches, neck stiffness, confusion, or neurological problems. It’s often used alongside other tests to diagnose conditions such as meningitis, encephalitis, or subarachnoid hemorrhage.

What Does an Abnormal Result Mean?

Elevated protein levels in CSF can indicate inflammation, infections, or blood leakage into the brain’s protective fluid. Lower-than-expected levels may suggest certain genetic or metabolic disorders. Results are interpreted in the context of your symptoms and other tests.

How Is This Test Performed?

A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap). A needle is inserted into your lower back, and fluid is gently withdrawn into a vial for testing.

What Should You Expect Before the Test?

You may be asked to empty your bladder beforehand and wear loose clothing. Avoid heavy lifting or strenuous activity for 24 hours before the procedure to reduce discomfort. Inform your provider if you have a history of bleeding disorders or severe back pain.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CSF Protein Level

Frequently asked questions

What are the normal ranges for this test?
Normal protein levels in CSF typically range between 15 to 45 milligrams per deciliter (mg/dL), but this can vary based on age, health conditions, and testing methods. Your results will be compared to your specific lab’s reference ranges and clinical picture.
How soon will I get my results?
Results are usually available within 1 to 3 business days, depending on your lab. Your healthcare provider will discuss them with you during a follow-up visit.
Can I take anything to prepare for this test?
No special preparation is needed beyond avoiding heavy lifting or strenuous activity for 24 hours before the procedure. Follow your provider’s instructions for any specific precautions related to your health conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy