Gluten Immunoglobulin G (IgG) Antibody, Serum
This test measures the level of antibodies your body produces in response to gluten, a protein found in wheat and related grains. It helps determine if you may have an unintentional sensitivity to gluten, even if you don’t have celiac disease.
["This test can help identify possible gluten sensitivity that isn’t linked to celiac disease or wheat allergy."]
Key facts at a glance
- LOINC
- 63155-6
- Short code
- Cultivated Wheat IgG-mCnc
- Synonyms
- Cultivated Wheat IgG-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test detects specific antibodies (IgG) your immune system creates when exposed to gluten. These antibodies are part of your body’s immune response and can be present even if you don’t have classic symptoms of celiac disease or wheat allergy. The result doesn’t directly measure gluten levels in your body but indicates if your immune system has reacted to it.
Why Might You Need This Test?
Doctors may recommend this test if you have symptoms like bloating, digestive issues, fatigue, or unexplained health concerns that don’t fit a known diagnosis. It’s also sometimes used in people with suspected gluten sensitivity who don’t meet the criteria for celiac disease or non-celiac gluten sensitivity.
What to Expect Before the Test
No special preparation is usually needed, but you may be asked to avoid certain medications or supplements that could affect results. Your doctor will confirm any specific instructions before the test.
What to Expect During the Test
A small blood sample will be taken from a vein in your arm. You may feel a slight pinch, but it’s generally quick and not painful. The sample is then sent to a lab for analysis.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
High IgG antibody levels may suggest an unintentional sensitivity to gluten, which can cause symptoms like digestive discomfort, fatigue, or other health issues. However, this test alone doesn’t diagnose celiac disease or wheat allergy. It’s often used alongside other tests or a gluten-free trial to better understand your health concerns.
Short name
Gluten IgG Antibodies
Frequently asked questions
Will this test diagnose celiac disease?
What does a high or low result mean?
Can I eat gluten before the test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy