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Progesterone, Serum (Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of progesterone, a hormone produced by the ovaries, uterus, and adrenal glands, in your blood serum. It helps assess reproductive health and hormone balance.

Quick summary

["Progesterone levels can indicate fertility, menstrual cycle phases, or potential hormone-related conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
64658-8
Short code
Current other progesterone PhenX
Synonyms
Current other progesterone PhenX
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0.1
Ref high
20
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
phenx
CPT
84144
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test to evaluate ovarian function, diagnose conditions like polycystic ovary syndrome (PCOS), assess pregnancy-related hormone changes, or check for hormonal imbalances before fertility treatments. It can also be used during menstrual cycle tracking or to monitor conditions affecting hormone production.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab uses a specific protocol. Wear a comfortable shirt for easy access to your arm. If you’re taking hormonal medications (e.g., birth control), let your provider know, as this may affect results.

What the Test Results Mean

Results are interpreted based on your medical history, symptoms, and cycle phase (if applicable). Low levels may suggest issues like ovarian dysfunction or early pregnancy, while high levels could indicate pregnancy, certain tumors, or hormonal therapy. Your provider will discuss these findings in context with your care plan.

Common Conditions Monitored

This test is often used to diagnose or monitor conditions like endometriosis, ovarian cysts, menstrual irregularities, or hormone-related fertility challenges. It may also help assess adrenal or pituitary disorders indirectly by evaluating hormone interactions.

Reference range

Follicular: 0.1-1.5 ng/mL; Luteal: 2-20 ng/mLN/A

Specimen: serum

For females: inform if menstrual cycle status. For certain tests, timing within menstrual cycle may matter.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Progesterone

Frequently asked questions

When should I ask my provider about follow-up testing?
If your results fall outside expected ranges for your situation (e.g., unusually low/high during a specific phase of your cycle) or if you experience symptoms like irregular periods, fatigue, or unexplained weight changes, discuss further testing or evaluation with your provider.
What if I’m pregnant and this test is ordered?
Progesterone levels rise during early pregnancy to support implantation and maintain the uterine lining. If ordered, your provider will interpret results in relation to your gestational age and symptoms. High levels may indicate a healthy pregnancy, while low levels could signal risks like miscarriage and may prompt additional testing.
Can birth control pills affect this test?
Yes, hormonal contraceptives (including birth control pills) can suppress natural progesterone production. If you’re on these medications, your provider may adjust test timing or interpretation to avoid misleading results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy