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Serum or Plasma Creatinine Concentration (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or plasma. It helps assess kidney function.

Quick summary

["A creatinine test helps doctors check how well your kidneys are filtering waste from your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51697-1
Short code
CV2 Ab Titr SerPl IF
Synonyms
CV2 Ab Titr SerPl IF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
if
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Creatinine is a byproduct of muscle breakdown and is filtered out by your kidneys. High levels may indicate kidney problems, while low levels could suggest dehydration or muscle loss. This test is often used alongside other measures to monitor kidney health, especially in people with diabetes, high blood pressure, or other chronic conditions.

How the Test Works

Blood is drawn from a vein, usually in your arm. The sample is sent to a lab where it is analyzed to determine the creatinine concentration using a method like enzymatic or nephelometric techniques. Results are compared to a reference range to identify any potential issues.

Common Reasons for Testing

Doctors may order a creatinine test to evaluate kidney function, diagnose conditions like chronic kidney disease, monitor treatment progress for conditions affecting the kidneys, or check for signs of dehydration or other health issues.

What to Expect Before the Test

There are usually no special preparations needed for this test. You may be asked to fast for 8–12 hours before the test if it is part of a broader metabolic panel, but this is not always required. Avoid strenuous exercise or heavy meals 24 hours before testing to ensure accurate results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

High creatinine levels may signal impaired kidney function, as the kidneys struggle to remove waste products efficiently. Low levels might suggest dehydration, low muscle mass, or errors in testing. Regular monitoring of creatinine levels is critical for managing chronic kidney disease, heart conditions, and other systemic illnesses. Always discuss results with your healthcare provider to interpret them in the context of your overall health.

Short name

Creatinine Level

Frequently asked questions

What causes creatinine levels to be higher than usual?
Several factors can lead to elevated creatinine levels, including kidney disease, dehydration, severe muscle damage or injury, high blood pressure, or certain medications. Chronic conditions like diabetes or heart failure may also contribute. If you notice unexplained changes in your test results, talk to your doctor about possible causes and next steps.
What should I do if my creatinine level is low?
Low creatinine levels can sometimes indicate dehydration, low muscle mass, or errors in testing. If you have concerns, your doctor may recommend additional tests or ask about your diet, hydration status, and overall health. They may also check for conditions like liver disease, which can affect muscle breakdown and creatinine production.
Does diet affect creatinine levels?
Dietary habits can influence creatinine levels indirectly. High-protein diets may increase muscle mass, potentially raising creatinine levels, while dehydration can artificially lower them. Your doctor may suggest dietary adjustments or hydration strategies if needed, but always follow their guidance based on your specific health situation.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy