Cvaabsp2titrser
This test measures antibodies to Coxsackievirus A in your blood to help diagnose recent infection.
{"Detects immune response to Coxsackievirus A infection","Second specimen compared to first to confirm recent infection","Helps diagnose hand-foot-and-mouth disease and other Coxsackievirus infections"}
Key facts at a glance
- LOINC
- 40761-9
- Short code
- COXAAT2
- Synonyms
- CV A Ab sp2 Titr Ser
- Category
- cardiac
- Sample
- serum
- Container
- Serum separator tube (SST) or plain red top tube
- Units
- N/A
- Ref low
- 40
- Ref high
- 160
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- Immunofluorescence assay (IFA) or Enzyme-linked immunosorbent assay (ELISA)
- CPT
- 86658
- SNOMED
- 122442004
- Specimen volume
- 1-2 mL of serum
- Stability
- Room temperature: 8 hours; Refrigerated (2-8°C): 48-72 hours; Frozen (-20°C or below): several weeks. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 50
- Lipemia max
- 300
- Icterus max
- 20
- TAT
- 24–120 hours
- Order
- routine
What is this test?
The Coxsackievirus A Antibody Test (2nd specimen) is a blood test that measures the level of antibodies your immune system has produced against Coxsackievirus A. When you have a second blood sample taken (usually 2-4 weeks after the first), doctors can compare antibody levels to determine if you have a recent or past infection.
How is the test performed?
A healthcare professional will draw a blood sample from a vein in your arm. The blood is sent to a laboratory where technicians measure the level of Coxsackievirus A antibodies. This is the second of two blood samples—the first was likely taken during your initial illness, and this one shows how your immune system has responded over time.
What do the results mean?
A significant increase in antibody levels between the first and second blood samples indicates a recent or ongoing Coxsackievirus A infection. This is called seroconversion or a four-fold rise in titer. A positive result helps confirm infections like hand-foot-and-mouth disease, herpangina, or other illnesses caused by Coxsackievirus A.
Reference range
Negative: <1:40; Equivocal: 1:40-1:80; Positive: ≥1:160. A four-fold rise in titer between acute and convalescent specimens (2nd specimen) indicates recent or acute infection.N/A
No special preparation required. Fasting is not necessary. Inform the laboratory of any recent viral infections or immunizations.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Frequently asked questions
Why do I need two blood samples?
Is fasting required before the test?
How long does it take to get results?
What should I do if my test is positive?
Sources
- 1
- 2
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 10, 2026. · Read our editorial policy